The majority of patients with scleroderma (~60–80%) have one of the following well-defined scleroderma autoantibodies: centromere (ACA), topoisomerase-1, or RNA polymerase III (RNApol3). Despite the fact that these antibodies have been recognized for decades, exciting new studies are just beginning to define their biologic underpinnings.

Scleroderma (systemic sclerosis) is associated with several autoantibodies, each of which is useful in the diagnosis of affected patients and in determining their prognosis. Anti-centromere antibodies (ACA) and anti-Scl-70 antibodies are very useful ...

The presence of anti-SCL-70 (anti-topoisomerase) antibodies is highly specific to the diagnosis of diffuse scleroderma, while the presence of anti-centromere antibodies is highly specific to the diagnosis of limited scleroderma.

The autoantibodies in your blood show what subset or type of scleroderma disease you have and your likely prognosis. There are nine known scleroderma-related autoantibodies that we can detect on current commercial blood tests.

2003年2月12日 · Scleroderma (systemic sclerosis) is associated with several autoantibodies, each of which is useful in the diagnosis of affected patients and in determining their prognosis.

2024年11月1日 · Scleroderma is associated with the presence of specific autoantibodies. These are proteins that can attack healthy tissues in your body. Here, we cover more about the role of antibodies in...

2023年1月23日 · Systemic sclerosis (SSc) belongs to the group of connective tissue diseases and is associated with the occurrence of disease-specific autoantibodies. Although it is still controversial whether these antibodies contribute to pathogenesis, there are ...

2016年6月14日 · This review discusses the current knowledge of autoantibodies in systemic sclerosis (SSc) with respect to clinical care. We focus primarily on the SSc-associated serum autoantibodies and their recognized SSc clinical phenotypes or characteristics. Geographic regional differences in autoantibody prevalence are discussed.

2022年11月1日 · Antinuclear autoantibodies (ANA) are central to the diagnosis of SSc. ANA specificities associated with distinct clinical patterns of organ and skin involvement. Understanding of the molecular differences and pathogenesis of …

Objective: Scleroderma-associated autoantibodies (SSc-Abs) are specific in participants (pts) with systemic sclerosis and are associated with organ involvement. Our objective was to assess the influence of baseline SSc-Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial.