Genomic findings in schizophrenia and their implications
2023年10月18日 · Genetic findings have revealed the nature of schizophrenia’s close relationship to other conditions, particularly BD and childhood NDDs and provided an explanation for how …
Genetics of Schizophrenia: Overview of Methods, Findings and ...
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots …
Schizophrenia genetics complements its mechanistic …
Refinement of genetic variants within the major histocompatibility complex reveals three distinct genetic influences on schizophrenia risk and sheds light on the disease’s neurobiology. The …
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
2022年4月8日 · The Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) consortium identified 32 genes with damaging ultra-rare mutations associated with schizophrenia (false …
Genomic findings in schizophrenia and their implications - PMC
Genetic findings have revealed the nature of schizophrenia’s close relationship to other conditions, particularly BD and childhood NDDs and provided an explanation for how common …
Schizophrenia’s strongest known genetic risk deconstructed
2016年1月27日 · The site in Chromosome 6 harboring the gene C4 towers far above other risk-associated areas on schizophrenia’s genomic “skyline,” marking its strongest known genetic …
Schizophrenia genomics: genetic complexity and functional …
2024年7月19日 · In this Review, we describe what we now know about the genetics of schizophrenia and consider the neurobiological implications of this information.
Single-cell multi-cohort dissection of the schizophrenia ... - Science
Schizophrenia population genomics has identified strong germline genetic associations for this highly heritable disorder, and molecular investigation of postmortem brain samples has yielded …
Genetic modifiers and subtypes in schizophrenia: Investigations …
Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for the disorder may differ between the sexes or between multiply affected families compared to …
Chromosomal Abnormalities and Schizophrenia - PMC
Schizophrenia is a common and serious psychiatric illness with strong evidence for genetic causation, but no specific loci yet identified. Chromosomal abnormalities associated with …