2024年12月25日 · SAP18 (Sin3A Associated Protein 18) is a Protein Coding gene. Diseases associated with SAP18 include Basal Cell Nevus Syndrome 1 and Pallister-Hall Syndrome. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and RNA Polymerase I Promoter Opening.

2023年7月24日 · As a part of EJC, SAP18 mediates alternative splicing events and suppresses the cryptic splice sites present within flanking regions of exon-exon junctions. In this review, we provide a thorough discussion on SAP18, focussing on its conserved dual role in transcriptional regulation and messenger RNA splicing.

2025年1月13日 · Dynamic shuttling of proteins between the nucleus and cytoplasm orchestrates vital functions in eukaryotes. Here, we reveal the multifaceted functions of Arabidopsis Sin3-associated protein 18 kDa (SAP18) in the regulation of development and heat-stress tolerance.

2019年1月22日 · Our data suggest a novel mechanism of vFLIP activation of the NF-κB by decreasing the SAP18/HDAC1 complex to promote the acetylation of p65 subunit, which contributes to vFLIP-induced...

2025年1月4日 · Title: Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. study indicates HIV-1 integrase & INI1/hSNF5 bind SAP18 & recruit components of Sin3a-HDAC1 complex into HIV-1 virions; HIV-1 virion-associated HDAC1 is required for efficient early post-entry events, indicating novel role for HDAC1 ...

2006年10月3日 · The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid.

2025年2月8日 · Functional role of SAP18 protein: From transcriptional repression to splicing regulation. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression.

2023年7月24日 · In this review, we provide a thorough discussion on SAP18, focussing on its conserved dual role in transcriptional regulation and messenger RNA splicing. Recent research on the involvement of SAP18 in the emergence of cancer …

2025年1月13日 · Dynamic shuttling of proteins between the nucleus and cytoplasm orchestrates vital functions in eukaryotes. Here, we reveal the multifaceted functions of Arabidopsis Sin3-associated protein 18 kDa (SAP18) in the regulation of development and heat-stress tolerance.

SAP18 is another polypeptide originally discovered by biochemical fractionation of human cell extracts and found to co-purify with the Sin3A/RPD3 HDAC complex in the enhancement of Sin3-mediated repression.