SW480 [SW-480] cells isolated from the large intestine of a Dukes C colorectal cancer patient and can be used in cancer research.

2024年9月20日 · Here, we leverage the SW480 cell line as a model system to investigate the molecular and functional diversity of colon cancer cells.

Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors. Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

SW480 Cell Line Derived Xenograft. SW480 is a human colon cancer cell line that was established from a primary adenocarcinoma of the colon. Colorectal cancer is the third most common cancer worldwide, and adenocarcinomas account for the majority of cases.

Excellent signal/background ratio and stable Luciferase expression make this cell line ideal for in vivo bioluminescence imaging of xenograft animal model to study human cancer and monitor activity of anti-cancer drug. It also can be used in cell-based assays for cancer research. Figure 1: In vivo detection of luciferase activity of SW480-Luc2.

The SW480 xenograft model is a preclinical model utilized in studies examining therapeutics targeting the β-catenin pathway (e.g. silibinin). The SW480 model also lends itself to studies addressing the link between human epidermal growth factor receptor (EGFR) expression levels and anti-tumor growth therapies (e.g. cetuximab).

2024年9月20日 · Here, we leverage the SW480 cell line as a model system to investigate the molecular and functional diversity of colon cancer cells.

The SW480 cell line originated from a surgical specimen of a primary tumor of a moderately differentiated colon adenocarcinoma. Organism: Human: Tissue: Colon: Disease: Adenocarcinoma, Grade IV, Dukes' type B. Synonyms: SW480, SW 480, SW480E

Human SW480 cell line has been used to study the antiproliferative effects of F. mughlea Pesmen on cancer cells. It has also been used as an in vitro model to study key cellular processes required for metastasis. The cell line is used to study the effects of the transforming growth factor-β (TGF-β) pathway and heat shock protein 90 (Hsp90) on the growth of cells.

SW480; SW480E; Culture Type: Cell line ; Keywords: Human Colon Adenocarcinoma Cell Line ; Description: Established a 50-year-old Caucasian male patient with colon adenocarcinoma (grade 4, Duke class B) Origin: Organism: Species: Human (Homo sapiens) Age: 50 years; Ethnicity: Caucasian; Gender: Male; Tissue: Large intestine, Colon