SUMO protein - Wikipedia
SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle. [1]
Mechanisms and functions of SUMOylation in health and disease: …
2024年1月27日 · SUMOylation, which is a type of post-translational modification that involves covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to target substrates, regulates various important molecular and cellular processes, including transcription, the cell cycle, cell signaling, and DNA synthesis and repair.
Signalling mechanisms and cellular functions of SUMO
2022年6月24日 · Sumoylation is an essential post-translational modification that is catalysed by a small number of modifying enzymes but regulates thousands of target proteins in a dynamic manner.
Concepts in sumoylation: a decade on | Nature Reviews …
Sumoylation is a highly dynamic process and its outcomes are extremely diverse, ranging from changes in localization to altered activity and, in some cases, stability of the modified protein.
Mechanisms, regulation and consequences of protein SUMOylation
SUMOylation involves the covalent attachment of a member of the SUMO (small ubiquitin-like modifier) family of proteins to lysine residues in specific target proteins via an enzymatic cascade analogous to, but distinct from, the ubiquitination pathway.
SUMOylation and deSUMOylation at a glance - PMC
Both SUMOylation and deSUMOylation (SUMO deconjugation) are highly dynamic processes. This poster article discusses the enzymes that mediate SUMOylation and deSUMOylation, concentrating on their mechanisms of action.
The post-translational modification, SUMOylation, and cancer …
SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis.
Introduction to Sumoylation - PubMed
Unlike ubiquitinylation which often leads to proteins turn over, sumoylation performs a variety of function such as altering protein stability, modulating protein trafficking, directing protein-protein interactions, and regulating protein activity.
Sumoylation as a Signal for Polyubiquitylation and Proteasomal ...
Sumoylation of proteins alters their biochemical properties in a way that may either promote a specific function, for example by enabling or enhancing an interaction with another protein, or inhibit a function by preventing interactions.
Sumoylation - an overview | ScienceDirect Topics
SUMOylation is the attachment of approximately 100 amino acids of small ubiquitin-like modifier (SUMO) to lysine residues [125]. SUMOylation alters the regulation of transcription, cell cycle, nucleocytoplasmic transport, DNA replication and repair, and apoptosis.