Serine/threonine kinase 11 (STK11) also known as liver kinase B1 (LKB1) or renal carcinoma antigen NY-REN-19 is a protein kinase that in humans is encoded by the STK11 gene. [5]

2022年8月12日 · STK11, also sometimes known as LKB1, is a gene that tells your body to make an enzyme called serine/threonine kinase 11. People who have a change, or mutation, in their STK11 gene, develop...

The STK11 gene (also called LKB1) provides instructions for making an enzyme called serine/threonine kinase 11. This enzyme is a tumor suppressor, which means that it helps keep cells from growing and dividing too fast or in an uncontrolled way.

2024年12月25日 · STK11 (Serine/Threonine Kinase 11) is a Protein Coding gene. Diseases associated with STK11 include Peutz-Jeghers Syndrome and Testicular Germ Cell Tumor. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.

We present three patients with STK11‐mutated tumors and discuss the proposed mechanisms by which germline and somatic alterations in STK11 promote carcinogenesis, potential approaches for therapeutic targeting, and the new data on resistance to immune checkpoint inhibitors.

STK11 overexpression prevents glucocorticoid-induced osteoporosis via activating the AMPK/SIRT1/PGC1alpha axis. Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer. STK11 Loss: A Novel Mechanism for Melanoma Metastasis with Therapeutic Implications.

2024年9月6日 · An inherited STK11 (Peutz-Jeghers Syndrome) mutation may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

What is the STK11 mutation? Errors in the STK11 gene are one type of lung cancer biomarker. Mutations in the STK11 gene (also called LKB1) inactivate the STK11 protein. This leads to uncontrolled cell growth, which can cause cancer. Who is most likely to have a STK11 mutation?

STK11 is a tumor suppressor gene that encodes for an enzyme called serine/threonine kinase 11 which is involved in AMPK pathway and regulates cell polarity. You might find these chapters and articles relevant to this topic. STK11 is known to be located both in the nucleus and the cytoplasm of all human tissues.

STK11 encodes for the protein liver kinase B1, a serine/threonine kinase which is involved in a number of physiological processes including regulation of cellular metabolism, cell polarity and the DNA damage response.