Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. [5] [6] [7] STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. [8] Even though the protein has been identified earlier, its function was unknown until recently.

Dec 25, 2024 · STIM1 (Stromal Interaction Molecule 1) is a Protein Coding gene. Diseases associated with STIM1 include Stormorken Syndrome and Immunodeficiency 10. Among its related pathways are Cardiac conduction and Platelet homeostasis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium channel regulator activity.

Jun 19, 2024 · STIM1（Stromal Interaction Molecule 1）是内质网膜上的一种钙传感器蛋白，主要功能是调控钙释放激活钙通道（CRAC通道）。 STIM1在内质网钙离子储存耗尽时，通过激活细胞膜上的Orai1通道，介导钙离子从细胞外进入细胞内，从而维持细胞内钙离子稳态。 2. **结构** 1. **N端区域**：位于内质网腔内，包含一个EF-hand钙结合结构域和一个SAM结构域，负责检测内质网内钙离子浓度。 2. **跨膜区**：单次跨膜结构域，将STIM1锚定在内质网膜上。 3. **C端区 …

该基因编码一种 1 型跨膜蛋白，该蛋白在细胞内 Ca2+ 储存耗尽后通过存储操作的 Ca2+ 流入通道 (SOC) 的门控介导 Ca2+ 流入。 它是位于 11p15.5 印迹基因域的几个基因之一，11p15.5 是一个重要的肿瘤抑制基因区域。 该区域的改变与 Beckwith-Wiedemann 综合征、肾母细胞瘤、横纹肌肉瘤、肾上腺皮质癌以及肺癌、卵巢癌和乳腺癌有关。 该基因可能通过介导与基质细胞的附着而在涉及该区域的恶性肿瘤和疾病以及早期造血中发挥作用。 该基因的突变与致命的经典卡波西肉 …

Jan 14, 2019 · Here, we found that deficiency in the Ca 2+ sensor stromal interaction molecule 1 (STIM1) caused spontaneous activation of STING and enhanced expression of type I interferons under resting...

Jul 27, 2015 · STIM1是免疫细胞中一种重要的内质网钙离子感受器，在机体对抗病原体过程中，STIM1蛋白感受到细胞内的钙离子变化，启动免疫细胞的开关，在免疫功能中起至关重要的作用。 近日，中科院强磁场科学中心王俊峰课题组与德州农工大学周育斌课题组、北京师范大学王友军课题组合作在STIM1蛋白的研究中取得进展，相关研究成果以“Inside-out Ca2+ signalling prompted by STIM1 conformational switch”为题发表在Nature Communications杂志上。 STIM1蛋白位于 …

The STIM1 gene provides instructions for making a protein called stromal interaction molecule 1 (STIM1). The STIM1 protein is involved in controlling the entry of positively charged calcium atoms (calcium ions) into cells when levels of the ions are low, specifically through channels called calcium-release activated calcium (CRAC) channels.

Stromal Interaction Molecule 1 (STIM1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Solid Tumors. STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.

1 day ago · By examining the dynamics of stromal interaction molecule 1 (STIM1), an endoplasmic reticulum (ER)-localized Ca2+ sensor that activates the Orai1 channel on the plasma membrane for SOCE and in mast cells, we found that a significant proportion of cells exhibited STIM1 oscillations with the same periodicity as Ca2+ oscillations. These cortical ...

在这里，作者展示了哮喘小鼠asm中内质网钙离子感应器基质相互作用分子1(stim1)的上调。 STIM1是支持气道REM的代谢和转录 重编程 所必需的。 图片来源: https:// doi.org/10.1073/pnas.21 14557118