Binary classification experiments on full sentences (negative or somewhat negative vs somewhat positive or positive with neutral sentences discarded) refer to the dataset as SST-2 or SST binary. The text in the dataset is in English (en). 'sentence': 'hide new secretions from the parental units ', 'label': 0} idx: Monotonically increasing index ID.

Soluble suppression of tumorigenicity-2 (sST2) is a biomarker widely investigated during the last few years. Its role has become clear in pathological conditions such as fibrosis and inflammation.

2019年10月21日 · sST2 is released in response to vascular congestion and inflammatory and profibrotic stimuli, and is a strong, independent predictor of mortality and HF hospitalization in patients with acute or chronic HF.

2021年7月22日 · Therefore, the present study aimed to investigate soluble ST2 (sST2) levels in patients with ischemic heart disease (IHD), myocardial infarction (MI), and heart failure (HF). A total of 1,425 studies were searched across four databases, of which 16 studies were included in the meta-analysis.

2020年2月1日 · Soluble suppression of tumorigenicity-2 (sST2) is a biomarker widely investigated during the last few years. Its role has become clear in pathological conditions such as fibrosis and inflammation.

Soluble suppression of tumorigenesis-2 (sST2) is released in response to vascular congestion and inflammatory and pro-fibrotic stimuli, and is a strong, independent predictor of mortality and heart failure (HF) hospitalization in patients with acute or chronic HF. sST2 meets 2 fundamental criteria for clinically useful biomarkers: accurate, repe...

Elevated levels of sST2 were identified as an adverse prognostic indicator, demonstrating a substantial association not only with overall mortality (combined HR 2.4, 95% CI 1.6-3.5, P < 0.01) but also with major adverse cardiovascular events (MACEs) (HR 2.5, 95% CI 1.5-4.2, P < 0.01).

2019年1月13日 · We show in a well‐characterized subset of heart failure patients with clinically suspected and biopsy‐confirmed myocarditis that elevated sera sST 2 is associated with an increased risk of heart failure based on New York Heart Association class …

ST2 has two main isoforms, ST2L and soluble isoform of ST2 (sST2), by alternative splicing. The interaction between interleukin (IL)-33 and the transmembrane isoform ST2L is up-regulated in response to myocardial stress and exerts cardio-protective actions in …

2024年10月25日 · sST2 has significant long-term predictive value for clinical outcomes in patients with AHF, particularly for those with a prior MI history, indicating a need for heightened clinical attention and thorough follow-up to mitigate long-term adverse cardiovascular outcomes.

ST2 (suppression of tumorigenicity 2) protein has gained interest as a potential biomarker in cardiovascular disease. It is known that the IL-33/ST2L system belongs to the cardioprotective pathway, which prevents the fibrosis, hypertrophy, and apoptosis of cardiomyocytes and also inhibits the inflammatory response.

2024年1月9日 · Soluble suppression of tumorigenicity‐2 (sST2) is a prognostic indicator for mortality in patients with heart failure and may help in risk stratification in patients with heart failure. 1 Although the mechanism has not been elucidated completely, it is known that sST2 is part of the suppression of tumorigenicity‐2 (ST2)/interleukin 33 (IL ...

Soluble suppression of tumorigenicity 2 (sST2) is a member of the interleukin-1 receptor family. It is raised in various cardiovascular diseases, but its value in predicting disease severity or mortality outcomes has been controversial.

2023年6月11日 · One such biomarker is soluble suppression of tumorigenicity-2 (sST2), which has shown some potential for integration into clinical practice. sST2 is produced by both cardiac fibroblasts and cardiomyocytes in response to myocardial stress.

2018年12月13日 · In an experimental model of heart failure, soluble ST2 (interleukin-1 receptor-like 1) is upregulated in lungs and secreted by pneumocytes in response to strain. In patients with cardiogenic pulmonary edema, soluble ST2 is present at …

2019年10月29日 · Soluble suppression of tumorigenesis-2 (sST2) is released in response to vascular congestion and inflammatory and pro-fibrotic stimuli, and is a strong, independent predictor of mortality and heart failure (HF) hospitalization in patients with acute or chronic HF. sST2 meets 2 fundamental criteria for clinically useful biomarkers: accurate, repe...

sST2 is a member of the IL-1 receptor family and is currently well studied in its two isoforms, the soluble form (sST2) and the transmembrane form (ST2L). sST2 is mainly released by vascular endothelial cells and expressed by hematopoietic and …

2023年1月18日 · We examined sST2 levels using an ELISA kit for myocarditis (n = 303), cardiomyopathy (n = 293), coronary artery disease (CAD) (n = 239), myocardial infarct (MI) (n = 159), and congestive heart failure (CHF) (n = 286) and compared them to controls that did not have CVDs (n = 234).

2021年7月23日 · Biomarkers such as B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-proBNP), cardiac troponin (cTn), and CK-MB contribute significantly to the diagnosis of cardiovascular disease (CVD).

Soluble interleukin 1 receptor-like 1 (sST2) is a novel predictor of poor outcomes, which is involved in inflammatory response and fibrosis of myocarditis.