A feature of the SREBP pathway is the proteolytic release of a membrane-bound transcription factor, SREBP. Proteolytic cleavage frees it to move through the cytoplasm to the nucleus. Once in the nucleus, SREBP can bind to specific DNA sequences (the sterol regulatory elements or SREs) that are found in the control regions of the genes that ...

Insulin modulates the SREBP pathway through transcriptional and post-transcriptional mechanisms that emerge from the mTOR pathway. Modulation of the SREBP pathway contributes to innate immunity and development of cancer. Acknowledgments

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a range of enzymes required for endogenous cholesterol, fatty acid (FA), triacylglycerol and phospholipid synthesis. The three SREBP isoforms, SR …

Aug 29, 2017 · SREBP directly induces expression of oncogenic IDH1 and increases production of 2-hydroxyglutarate, a key oncometabolic regulator produced from glucose, which demonstrates that SREBPs can...

SREBP-1c regulates transcription of genes involved in FAs, such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), two crucial DNL regulation enzymes, and triacylglycerol synthesis, whereas SREBP-1a stimulates both FAs and cholesterol synthesis.

Changes in cell metabolism and growth are reciprocally linked through SREBPs. Anabolic and growth signalling pathways branch off and connect to multiple steps of SREBP activation and form complex regulatory networks.

The SREBPs play related but distinct roles: SREBP-1c, the predominant SREBP-1 isoform in adult liver, preferentially activates genes required for fatty acid synthesis, while SREBP-2 preferentially activates the LDL receptor gene and various genes required for …

Sterol regulatory element binding protein (SREBP) is a membrane-bound transcription factor that regulates cellular lipogenesis and lipid homeostasis [281]. The correlation between SREBP and the immunosuppressive TME has been widely reported.

May 2, 1997 · In humans, hamsters, and mice, two members of the SREBP family, designated SREBP-1a and SREBP-1c, are produced from a single gene (human chromosomal location, 17p11.2) through the use of alternate transcription start sites encoding alternate first exons that are spliced into a common second exon (Yokoyama et al. 1993; Hua et al. 1995b ...

Oct 3, 2012 · Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis.