A feature of the SREBP pathway is the proteolytic release of a membrane-bound transcription factor, SREBP. Proteolytic cleavage frees it to move through the cytoplasm to the nucleus. Once in the nucleus, SREBP can bind to specific DNA sequences (the sterol regulatory elements or SREs) that are found in the control regions of the genes that ...

Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [ 5 ] [ 6 ]

Insulin modulates the SREBP pathway through transcriptional and post-transcriptional mechanisms that emerge from the mTOR pathway. Modulation of the SREBP pathway contributes to innate immunity and development of cancer. Acknowledgments

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a range of enzymes required for endogenous cholesterol, fatty acid (FA), triacylglycerol and phospholipid synthesis. The three SREBP isoforms, SR …

2017年8月29日 · SREBP directly induces expression of oncogenic IDH1 and increases production of 2-hydroxyglutarate, a key oncometabolic regulator produced from glucose, which demonstrates that SREBPs can...

The SREBP family plays a key role in lipid homeostasis (cholesterol and triglyceride). Moreover, SREBPs are also involved in the normal functions of some organs. One of these organs is the thyroid.

The SREBPs play related but distinct roles: SREBP-1c, the predominant SREBP-1 isoform in adult liver, preferentially activates genes required for fatty acid synthesis, while SREBP-2 preferentially activates the LDL receptor gene and various genes required for …

Changes in cell metabolism and growth are reciprocally linked through SREBPs. Anabolic and growth signalling pathways branch off and connect to multiple steps of SREBP activation and form complex regulatory networks.

Sterol regulatory element binding protein (SREBP) is a membrane-bound transcription factor that regulates cellular lipogenesis and lipid homeostasis [281]. The correlation between SREBP and the immunosuppressive TME has been widely reported.

1997年5月2日 · In humans, hamsters, and mice, two members of the SREBP family, designated SREBP-1a and SREBP-1c, are produced from a single gene (human chromosomal location, 17p11.2) through the use of alternate transcription start sites encoding alternate first exons that are spliced into a common second exon (Yokoyama et al. 1993; Hua et al. 1995b ...

2012年10月3日 · Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis.

SREBP-1c regulates transcription of genes involved in FAs, such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), two crucial DNL regulation enzymes, and triacylglycerol synthesis, whereas SREBP-1a stimulates both FAs and cholesterol synthesis.

2019年3月22日 · SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins.

2013年1月1日 · The effects of mTORC1 on SREBP can be divided into three levels: (i) transcription level, mTORC1 can elevate SREBP-1c mRNA; (ii) proteolytic processing level, mTORC1 can enhance proteolytic processing through activating S6K; (iii) n-SREBP level, mTORC1 can repress Lipin-1 to increase n-SREBP abundance.

2016年1月21日 · Low levels of oxysterols and/or unsaturated fatty acids relieve Insig1-mediated ER-retention, causing SREBP movement to the golgi, proteolytic processing at two cleavage sites (red arrow heads), and nuclear localization.

2001年11月1日 · SREBPs have unique characteristics. Firstly, they are membrane-bound proteins and the N-terminal active portions enter nucleus to activate their target genes after proteolytic cleavage, which requires sterol-sensing molecule, SREBP-activating protein (SCAP) and is crucial for sterol-regulation.

In contrast, SREBP1c functions primarily in the liver to drive fatty acid synthesis, while SREBP1a can drive both pathways in all tissues. However, understanding the tissue-specific and differential genetic requirements for each SREBP has proven elusive.

Current models suggest that SREBP plays a passive role prior to cleavage. However, we show that SREBP actively prevents premature recycling of SCAP-SREBP until initiation of SREBP cleavage. SREBP regulates SCAP in human cells and yeast, indicating that this is an ancient regulatory mechanism.

The essential function of sterol regulatory element-binding proteins (SREBPs) in cellular lipid metabolism and homeostasis has been recognized for a long time, and the basic biological pathway involving SREBPs has been well described; however, a rapidly growing number of studies reveal the complex regulation of these SREBP transcription factors ...

2012年2月1日 · SREBP-1c is the predominant isoform in most adult non-dividing metabolic tissues such as liver and adipose. The SREBP-1c promoter is autoregulated by SREBPs [3] and stimulated by both liver X receptor (LXR) and insulin signaling.