Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene. [5][6] …

2024年12月25日 · SPINK5 (Serine Peptidase Inhibitor Kazal Type 5) is a Protein Coding gene. Diseases associated with SPINK5 include Netherton Syndrome and Ichthyosis Linearis …

At least 70 SPINK5 gene mutations have been identified in people with Netherton syndrome, a disorder involving skin and hair abnormalities and a high risk of allergies, asthma, and an …

2024年2月5日 · Here we describe a novel and viable, Spink5 conditional knock-out (cKO) mouse model, allowing to study NS progression. By combining transcriptomics and proteomics, we …

Serine peptidase inhibitor kazal type 5 (SPINK5) emerged as a potential key gene mediating the formation of EETs in HNSCC. EETs not only exhibit a positive correlation with diverse anti …

Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier gene have previously been associated with allergic conditions. Objective: To determine whether genetic …

2022年2月10日 · SPINK5 Can Serve as a Tumor Prognostic Marker and Inhibits Tumor Progression Through Multiple Mechanisms. The SPINK5 gene is located in the 5q32 region …

2004年12月26日 · Mutations in SPINK5, encoding the serine protease inhibitor LEKTI, cause Netherton syndrome, a severe autosomal recessive genodermatosis. Spink5−/− mice faithfully …

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Orphanet is part of the Gene …

2006年2月1日 · Here, we report the characterization and expression analysis of two novel SPINK5 messenger RNAs (mRNAs) that are generated by alternative processing of the …