
LEKTI - Wikipedia
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene. [5][6] LEKTI is a large multidomain serine protease inhibitor expressed in stratified epithelial tissue.
SPINK5 Gene - GeneCards | ISK5 Protein | ISK5 Antibody
2024年12月25日 · SPINK5 (Serine Peptidase Inhibitor Kazal Type 5) is a Protein Coding gene. Diseases associated with SPINK5 include Netherton Syndrome and Ichthyosis Linearis Circumflexa. Among its related pathways are Developmental Cell Lineages and Keratinization.
SPINK5 gene - MedlinePlus
At least 70 SPINK5 gene mutations have been identified in people with Netherton syndrome, a disorder involving skin and hair abnormalities and a high risk of allergies, asthma, and an inflammatory skin condition called eczema.
Comparative analyses of Netherton syndrome patients and Spink5 …
2024年2月5日 · Here we describe a novel and viable, Spink5 conditional knock-out (cKO) mouse model, allowing to study NS progression. By combining transcriptomics and proteomics, we determine a disease...
SPINK5 is a key regulator of eosinophil extracellular traps in head …
Serine peptidase inhibitor kazal type 5 (SPINK5) emerged as a potential key gene mediating the formation of EETs in HNSCC. EETs not only exhibit a positive correlation with diverse anti-cancer pathways but also demonstrate positive associations with processes such as proliferation, migration, and other critical pathways.
The skin barrier function gene SPINK5 is associated with ... - PubMed
Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier gene have previously been associated with allergic conditions. Objective: To determine whether genetic variants in and around SPINK5 are associated with IgE-mediated food allergy.
SPINKs in Tumors: Potential Therapeutic Targets - Frontiers
2022年2月10日 · SPINK5 Can Serve as a Tumor Prognostic Marker and Inhibits Tumor Progression Through Multiple Mechanisms. The SPINK5 gene is located in the 5q32 region and consists of 15 functional regions, encoding a 15-domain classical and nonclassical Kazal inhibitor called lymphoepithelial Kazal-related inhibitor (LEKTI) .
Spink5-deficient mice mimic Netherton syndrome through
2004年12月26日 · Mutations in SPINK5, encoding the serine protease inhibitor LEKTI, cause Netherton syndrome, a severe autosomal recessive genodermatosis. Spink5−/− mice faithfully replicate key features of...
Orphanet: SPINK5-serine peptidase inhibitor Kazal type 5
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. Orphanet is part of the Gene Curation Coalition, a global effort to harmonise gene-level resources.
SPINK5, the Defective Gene in Netherton Syndrome, Encodes …
2006年2月1日 · Here, we report the characterization and expression analysis of two novel SPINK5 messenger RNAs (mRNAs) that are generated by alternative processing of the SPINK5 pre-mRNA.