Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene. [5][6][7] This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate.

2024年12月25日 · SOX11 (SRY-Box Transcription Factor 11) is a Protein Coding gene. Diseases associated with SOX11 include Intellectual Developmental Disorder With Microcephaly And With Or Without Ocular Malformations Or Hypogonadotropic Hypogonadism and Hypogonadotropic Hypogonadism .

Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors.

The SOX11 gene provides instructions for making a protein that plays a critical role in the development of the brain and nerve cells (neurons). Learn about this gene and related health conditions.

2020年12月1日 · We review studies that show roles for SOX11 in regulating development of a variety of embryonic tissues and those that indicate SOX11 as a key regulator of progenitor/ stem cells.

SRY-box transcription factor 11 (SOX11), as a member of the SOX family, is a transcription factor involved in the regulation of specific biological processes and has recently been found to be a prognostic marker for certain cancers. However, the roles …

2023年3月7日 · In this work, we show that SOX11 acts as a master transcription and dependency factor in adrenergic NB cells. We identify and validate SOX11 target genes which includes genes involved in...

SOX11 expression is restricted to EBV-negative Burkitt lymphoma and is associated with molecular genetic features. SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma. SOX11/PRDX2 axis modulates redox homeostasis and chemoresistance in aggressive mantle cell lymphoma.

SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis. Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma [1].

SOX11 showed prominent expression in neuroectodermal tumours with neural differentiation, high grade-NEC, SDC, rhabdomyosarcoma and MRCL. The high sensitivity and specificity of SOX11 in SDC and MRCL make it a useful diagnostic marker.