Dec 25, 2024 · SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with SOS1 include Noonan Syndrome 4 and Fibromatosis, …

Jan 15, 2025 · Here we used the newly developed cryo nanoscale secondary ion mass spectrometry ion microprobe 1, which allows high-resolution elemental imaging of cryo …

The SOS1 gene provides instructions for making a protein that is involved in controlling (regulating) the activation of the RAS/MAPK signaling pathway, which helps control several …

Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents a unique opportunity for treating RAS-addicted …

Jun 12, 2021 · We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting predominant involvement of mitochondria in …

Jun 29, 2020 · The contributions of wild-type RAS to proliferation and transformation in RAS-mutated cancer cells places renewed interest in upstream signaling molecules, including the …

Oct 26, 2023 · From our structural and functional analyses, we propose a model for how the unique large cytoplasmic domain regulates the Na + /H + exchange activity of SOS1, …

Sep 19, 2024 · Title: SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway. Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation …

Specific SOS1 gain-of-function mutations have been identified in inherited RASopathies and various sporadic human cancers. SOS1 depletion reduces tumorigenesis mediated by RAS or …

We report on a novel pathogenic mutation in the SOS1 gene and a large clinical spectrum in a Noonan syndrome family with ten genetically confirmed affected individuals. Data indicate …

Dec 23, 2024 · The plasma membrane (PM)-localized Na+/H+ antiporter Salt Overly Sensitive1 (SOS1) is essential for plant salt tolerance through facilitating Na+ efflux; however, how SOS1 …

Jan 2, 2025 · Our findings suggest that SOS1 PROTACs may potentially serve as a valuable option for exploring the biological functions of SOS1 and as a basis for developing novel …

Although all the types of diabetes result in high blood sugar levels over a prolonged period, Type 1 diabetes is said to be an autoimmune disorder which results in the destruction of insulin …

Aug 5, 2024 · Here, we assessed the antitumor responses of KRAS G12C mutant lung and colorectal cancer models to combination treatment with a SOS1 inhibitor (SOS1i), BI-3406, …

Jun 1, 2021 · Son of Sevenless (SOS) is a guanine nucleotide exchange factor that activates the important cell signaling switch KRAS. SOS acts as a pacemaker for KRAS, the beating heart …

Dec 5, 2023 · In this review, we provide a comprehensive overview of the structure, biological function, and regulation of SOS1. We also focus on the recent advances in SOS1 inhibitors …

May 18, 2021 · SOS1, a KRAS activator and important feedback node, represents an effective approach to treat KRAS-driven cancers. BI-3406 is a highly potent, selective, and orally …

The M-Ras GTP/GDP cycle was sensitive to the Ras GEFs, Sos1, and GRF1 and to p120 Ras GAP. Together, these findings suggest that while M-Ras is regulated by similar upstream …

Jan 15, 2025 · 研究人员发现在根分生组织中，NHX家族钠/质子拮抗剂SALT OVERLY SENSITIVE 1（又称 Na + /H + 交换子 7；SOS1/NHX7）的一个关键功能是将钠封闭在液泡中，而不是将 …

Oct 9, 2020 · It is important to note that we did not include the start of season of the first cropping cycle (SOS1) in our analysis due to limited records at the in situ stations. The methods can be …