Jan 1, 2016 · Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal structures of SOCS2 to discuss the potential effects of a selection of SOCS2 mutations that were identified in tumour tissues.

Dec 25, 2024 · SOCS2 (Suppressor Of Cytokine Signaling 2) is a Protein Coding gene. Diseases associated with SOCS2 include Hematologic Cancer and Polycythemia Vera. Among its related pathways are IL-9 Signaling Pathways and Metabolism of proteins.

SOCS2 knockdown reduced growth of AML cells in vitro and delayed disease upon transplantation into mouse models, with these cells showing mature myeloid cell markers (172), suggesting a potential oncogenic role for SOCS2.

May 18, 2007 · Suppressor of cytokine signalling (SOCS) proteins are inhibitors of cytokine signalling pathways. Studies have shown that SOCS proteins are key physiological regulators of both innate and...

The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation, yet the ...

Aug 28, 2023 · SOCS2 is a member of the suppressor of cytokine signaling (SOCS) family and is a cytokine-inducible negative regulator of cytokine receptor signaling through the JAK/STAT pathway.

Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal structures of SOCS2 to discuss the potential effects of a selection of …

Mar 11, 2025 · Here we investigated the role of Socs2, a negative regulator of cytokine signaling, in modulating the response to pegIFNα in a JAK2-V617F mouse model of MPN.

Specific studies targeting the SOCS genes in vivo have unveiled SOCS2 as the main regulator of somatic growth through regulation of GH/IGF-1 signaling. In addition, several studies indicate that SOCS2 also has important actions in the central nervous system, the regulation of metabolism, the immune response, the mammary gland development ...

Dec 28, 2015 · Here, we focus on SOCS2 and review its biological function as well as its implication in pathological processes. Furthermore, we take advantage of the known crystal structures of SOCS2 to...