Sorting nexin family member 27, also known as SNX27, is a human gene. [5] This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane …

Dec 25, 2024 · SNX27 (Sorting Nexin 27) is a Protein Coding gene. Diseases associated with SNX27 include Dravet Syndrome and Charcot-Marie-Tooth Disease Type 4K . Gene Ontology …

Sep 20, 2019 · Here we report on the mass spectrometric identification of the OTULIN interactor SNX27 (sorting nexin 27), an adaptor of the endosomal retromer complex responsible for …

Sorting nexin 27 (SNX27) is a metazoan-specific sorting nexin protein from the PX-FERM domain family and is required for endosomal recycling of many important transmembrane receptors. …

SNX27 belongs to the sorting nexin (SNX) family of proteins that play a critical role in protein sorting and trafficking in the endocytosis pathway. This protein family is characterized by the …

Apr 7, 2013 · Our data identify the SNX27–retromer as a major endosomal recycling hub required to maintain cellular nutrient homeostasis. Following internalization, endocytosed …

Jan 25, 2022 · Recent studies show ACE2 possesses a type I PDZ binding motif (PBM) through which it could interact with a PDZ domain-containing protein such as sorting nexin 27 …

Dec 22, 2022 · In this review, we summarize the structure and fundamental roles of SNX proteins, with a focus on SNX27, and provide the current evidence indicating towards the role of SNX27 …

Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor that shapes excitatory control, being relevant for cognitive and reward processing, and for several …

Feb 9, 2025 · FERM_F1_SNX27; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 27 (SNX27) RefSeqs of Annotated Genomes: …

Feb 9, 2025 · SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling …

SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, …

Jul 12, 2021 · The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most …

Mar 24, 2013 · Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking. Here we show that Snx27−/− mice have severe neuronal …

May 4, 2018 · Here we identify ASCT2 as a membrane-trafficked cargo molecule, sorted through a direct interaction with the PDZ domain of sorting nexin 27 (SNX27). Using both membrane …

Nov 27, 2020 · Sorting nexin 27 (SNX27) is an endosomal adaptor protein associated with a variety of nervous system diseases, and it is mainly responsible for the trafficking of …

When endocytic pathway was used during SARS-CoV-2 infection, SNX27-retromer sorts ACE2/SARS-CoV-2 complex at early endosome and prevents it from entering lysosome/late …

Nov 27, 2017 · Here we define a fundamental SNX27 function in T lymphocytes controlling antigen-induced transcriptional activation and metabolic reprogramming. SNX27 limits the …

Here we identify ASCT2 as a membrane-trafficked cargo molecule, sorted through a direct interaction with the PDZ domain of sorting nexin 27 (SNX27). Using both membrane …

Jan 1, 2022 · When endocytic pathway was used during SARS-CoV-2 infection, SNX27-retromer sorts ACE2/SARS-CoV-2 complex at early endosome and prevents it from entering …