Jan 1, 2006 · SLP76 (SH2-domain-containing leukocyte protein of 76 kDa) regulates signals from immunoreceptors, such as T-cell receptors, the high-affinity receptor for IgG (FcγRI), the...

Combining regulated deletion of endogenous SLP-76 with transgenic expression of a SLP-76 SH2 domain mutant, we demonstrate that the SLP-76 SH2 domain is required for peripheral T cell …

The adapter protein SH2 domain-containing leukocyte protein of 76 kDa (SLP-76) is an essential mediator of signaling from the T-cell antigen receptor (TCR). We report here that SLP-76 also …

Jan 15, 2002 · SLP-76 plays an important role in T cell receptor signal transduction and T cell activation. SLP-76-deficient Jurkat cells exhibit severely impaired TCR/CD3 signaling with …

Jan 1, 2018 · SLP-76, which functions as a signal transducer downstream of TCRs, is an adaptor protein that has three modular domains: an amino (N)-terminal acidic domain with three …

Jul 10, 2012 · SLP-76 serves to nucleate the formation of multiprotein signaling complexes and thereby supports signaling downstream of integrins and multiple immunoreceptors. Here, we …

Oct 5, 2012 · Here, we report that phosphorylated SLP-76 is ubiquitinated and targeted for proteasomal degradation during TCR signaling. SLP-76 ubiquitination is mediated by Ser-376 …

Aug 16, 1996 · As SLP-76 interacts with both Grb2 and phospholipase C-gamma1, these data indicate that phosphorylation of SLP-76 by ZAP-70 provides an important functional link …

Oct 5, 2012 · Here, we report that phosphorylated SLP-76 is ubiquitinated and targeted for proteasomal degradation during TCR signaling. SLP-76 ubiquitination is mediated by Ser-376 …

The SH2 domain-containing protein of 76 kDa, SLP76, is an important adaptor protein that coordinates a complex protein network downstream of T-cell receptors (TCR), ultimately …