2008年8月21日 · We have identified common variants in SLCO1B1 that are strongly associated with an increased risk of statin-induced myopathy. Genotyping these variants may help to achieve the benefits of...

The solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encodes for a membrane-bound sodium-independent organic anion transporter protein (OATP1B1) that is involved in active cellular influx of many endogenous and xenobiotic compounds.

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.

2024年12月25日 · SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include Hyperbilirubinemia, Rotor Type and Gilbert Syndrome.

SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein …

SLCO1B1 encodes for one of the major hepatic influx transport proteins organic anion transporting polypeptide 1B1 (OATP1B1), also referred to as SLCO1B1, and previously as OATP-C, OATP2, and liver specific transporter 1 (LST-1).

2018年9月17日 · Performing SLCO1B1 testing led to an increased willingness by providers to reinitiate statins and improved patient perceptions of statin therapy. This translated into a 20 mg/dL reduction in LDL-C levels during the trial in the GIST group and a 14.9 mg/dL reduction in the usual care group that received the pharmacogenetic test results at the ...

SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians. Sortica VA, et al. Clin Chem Lab Med, 2012 Mar. PMID 22505549

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. [5][6] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin. [7]

2024年12月10日 · Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. Human metabolic individuality in biomedical and pharmaceutical research.