Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the orthologous Sirt5 gene.

Dec 25, 2024 · SIRT5 (Sirtuin 5) is a Protein Coding gene. Diseases associated with SIRT5 include Urea Cycle Disorder and Hypertrophic Cardiomyopathy. Among its related pathways are NAD metabolism and Transcriptional activation of mitochondrial biogenesis.

Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mitochondrial matrix. SIRT5 plays a key role in metabolism and antioxidant responses, and is an important regulator for maintaining intracellular homeostasis.

Nov 2, 2023 · SIRT5 is a lysine deacylase that regulates multiple metabolic pathways, including energy metabolism. We have previously reported that a subset of acute myeloid leukemia (AML) cases depends on SIRT5 as a master regulator of central energy metabolism, implicating SIRT5 as a therapy target in AML.

Aug 30, 2024 · Recent studies have highlighted the potential role of SIRT5 in various human diseases, including MIRI. This study aims to investigate the specific role of SIRT5 in modulating autophagy and cardiomyocyte death in a MIRI model, as well as to identify the downstream protein targets of SIRT5.

Jan 28, 2025 · SIRT5 stands out due to its defined role in mitochondrial function and its dependence on NAD+, distinguishing it from potential non-sirtuin desuccinylases that might operate through different mechanisms and within distinct cellular contexts.

Nov 26, 2024 · Here we report a cardioprotective role of the mitochondrial protein Sirt5 in a mouse model of cardiac IR injury. The down-regulation of Sirt5 in IR-injured heart is associated with an increased protein lactylation and impaired mitochondrial function.

Mar 9, 2023 · SIRT5 controls a wide range of aspects of myocardial energy metabolism and plays critical roles in heart physiology and stress responses. Moreover, SIRT5 has a protective function in the context of neurodegenerative diseases, while it acts as a context-dependent tumor promoter or suppressor.

Sirtiun 5（SIRT5）是一种 NAD+ 依赖性的蛋白质赖氨酸脱酰基酶，主要位于 线粒体 中。 SIRT5对带负电荷的酰基显示出亲和力，主要催化赖氨酸脱谷氨酰化、脱琥珀酰化和脱丙醇酰化，同时拥有弱的脱乙酰酶活性。 SIRT5底物在新陈代谢和活性氧（ROS）解毒中起着至关重要的作用，SIRT5的活性在神经元和心脏生理学中具有保护作用。 此外，SIRT5在癌症中表现出二分法 …

Feb 12, 2024 · Sirt5. Sirt5 exhibits a strong affinity for negatively charged acyl groups, such as glutaric, succinic, and malonic acids; catalyses mainly lysine acylation, but also desuccinylates and deglutarylates; and has weak deacetylase activity .