SHP2 是 PTP 家族中第一个被证实的原癌蛋白，是生长因子信号通路和免疫检查点信号通路的重要调节因子，参与 Ras/Raf/MEK/ERK 、 JAK/STAT 、 PI3K/AKT/mTOR 和 PD-1/PD-L1 等多种信号通路，与细胞增殖、迁移、分化和凋亡等密切相关，可以促进肿瘤的发生和发展。 SHP2 的活化突变或表达上调与肺腺癌、结肠癌、乳腺癌和黑色素瘤等多种实体瘤和白血病的发生有密切关系。 此外，SHP2 还介导了 MEK 等激酶被抑制之后的代偿性激活途径，从而促进肿瘤耐药。 SHP2 …

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in …

2000年12月1日 · SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is involved in the signaling pathways of a variety of growth factors and cytokines.

Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues. SHP2 modulates diverse cell signaling events that control metabolism, cell growth, differentiation, cell migration, transc …

This review focuses on the roles of the two cytoplasmic PTPs, the Src-homology 2 domain (SH2)-containing SHP-1 and SHP-2, in T-cell signaling, development, differentiation, and function. Keywords: SHP-1, SHP-2, T cells, motheaten mice, T-cell signaling, T-cell development

2022年11月21日 · 含srC同源-2的蛋白酪氨酸磷酸酶2（SHP2），由PTPN11编码，是一种去磷酸化酶，属于蛋白酪氨酸磷酸酶（PTPs）家族。 SHP2作为包括Ras-Raf-MEK-ERK、JAK-STAT、PI3K-AKT-mTOR和PD-1/PD-L1通路在内的多种信号通路的汇聚节点，可以增强或拮抗与经典细胞存活相关的和具有底物特异 ...

2024年3月4日 · SHP-2 is a key intracellular regulatory factor mediating cell proliferation and differentiation and is involved in a variety of growth factor and cytokine signaling pathways linking the cell surface to the nucleus.

SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease. SHP-2 has been clearly demonstrated to be an important molecule in various cytoplasmic signal ...

2020年5月27日 · SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally, SHP2 serves as an important hub to connect several intracellular oncogenic signaling pathways, such as Jak/STAT, PI3K/AKT, RAS/Raf/MAPK, and PD-1/PD-L1 pathways.

2020年2月1日 · Several studies have shown that SHP2 plays an important role in regulating immune cell functions in tumor microenvironment. A few clinical trials conducted using SHP2 allosteric inhibitors have shown remarkable anti-tumor benefits and good safety profiles.