SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. [5] . SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells. SCOP classifies the 3D structure as belonging to the SH2 domain family.

2024年12月25日 · SHC1 (SHC Adaptor Protein 1) is a Protein Coding gene. Diseases associated with SHC1 include Breast Cancer and Multiple Endocrine Neoplasia, Type Iia. Among its related pathways are IL-9 Signaling Pathways and Downstream signaling of activated FGFR2.

SHC1 expression was associated with five MMR genes in human pan-cancers, especially in liver cancer. SHC1 expression was also positively correlated with three DNMTs (DNMT1, DNMT3A, and DNMT3B) in human cancers, especially in DLBC, KICH, KIRC, KIRP, LGG, LIHC, LUAD, MESO, TGCT, and UVM.

p66Shc (SHC1) protein through a redox mechanism enhances the progression of prostate cancer cells towards castration-resistance. In B cell lymphoma cells, reactive oxygen species production promoted p66shc expression, induced DNA damage, and facilitated cell apoptosis.

2025年2月9日 · Title: MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis. YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation via SHC1.

SHC1 links to Ras pathways that activate receptor tyrosine kinases through GRB2/SOS. However, further research is needed to explore its mechanism in tumors. SHC1 is also involved in the regulation of oxidative stress, apoptosis, and senescence.

2002年8月1日 · Shc1 (which encodes ShcA) was identified 10 years ago by screening a cDNA library at low stringency with a probe encoding an SH2 domain. Shc1 is ubiquitously expressed, whereas Shc2 and Shc3...

The Shc family consists of four members encoded by four distinct genes: Shc/Shc1/ShcA, Sli/Shc2/ShcB, Rai/Shc3/ShcC and RaLP/Shc4/ShcD (Figure 1). Broadly, Shc proteins contribute to mediating several intracellular signalling cascades; they are implicated in cell proliferation, cell differentiation, cell survival and migration [ 7 , 8 , 9 ].

2024年8月30日 · SHC1 plays a crucial regulatory role in various tumors, but its significance in predicting prognosis and immune response in clear cell renal cell carcinoma (ccRCC) is yet to be determined.

2021年5月20日 · This research aimed to identify if p66shc a component of the Human SHC‐Transforming Protein 1 (Shc1), a mitochondrial associated oxidative stress biomarker, is significantly altered in patients with elevated BGL.