
SF3B1 - Wikipedia
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene. [5][6] This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and U2 spliceosomal RNA, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP).
SF3B1 : the lord of the rings in MDS - American Society of …
2020年7月9日 · MDS patients with somatic SF3B1 mutations share a common phenotype, with favorable outcomes and a restricted spectrum of subclonal mutations, independently of their WHO 2017 category. Malcovati et al propose a new MDS subtype characterized by SF3B1 mutations, following the classification criteria depicted in the figure. Abn, abnormalities; BM ...
SF3B1 mutations in myelodysplastic syndromes: A potential …
Increasing evidence that knockdown or exogenous overexpression of SF3B1 mutations regulates tumorigenesis and progression of MDS suggests that SF3B1 represents a potential therapeutic target, and there is an urgent need for appropriate therapeutic strategies.
SF3B1 Gene - GeneCards | SF3B1 Protein | SF3B1 Antibody
2024年12月25日 · SF3B1 (Splicing Factor 3b Subunit 1) is a Protein Coding gene. Diseases associated with SF3B1 include Myelodysplastic Syndrome and Chronic Myelogenous Leukemia, Bcr-Abl1 Positive. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and RNA Polymerase I Promoter Opening.
The biological function and clinical significance of SF3B1 …
SF3B1 is the largest subunit of the spliceosome factor 3b (SF3B) complex, which is a core component of spliceosomes. Recurrent somatic mutations in SF3B1 have been detected in human cancers, including hematological malignancies and solid tumors, and indicated to be related to patient prognosis.
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
2011年10月13日 · Follow-up revealed SF3B1 mutations in 72 of 354 patients (20%) with myelodysplastic syndromes, with particularly high frequency among patients whose disease was characterized by ring...
SF3B1 Gene Mutations and Their Significance for Patients with ...
2024年11月5日 · The mutations of splicing factor genes (e.g., SF3B1, SRSF2, U2AF1, ZRSR2) are found in approximately 60% of MDS patients and lead to the accumulation of R-loops and associated DNA damage, resulting in the activation of the ATR pathway in affected cells.
SF3B1-mutant MDS as a distinct disease subtype: a proposal from …
2020年7月9日 · Approximately half of MDS patients carry somatic mutations in spliceosome genes, with SF3B1 being the most commonly mutated one. SF3B1 mutation identifies a condition characterized by ring sideroblasts (RS), ineffective erythropoiesis, and indolent clinical course.
SF3B1-mutant MDS as a distinct disease subtype: a proposal from …
2020年7月9日 · SF3B1 mutation identifies a condition characterized by ring sideroblasts (RS), ineffective erythropoiesis, and indolent clinical course. A large body of evidence supports recognition of SF3B1-mutant MDS as a distinct nosologic entity.
SF3B1 splicing factor 3b subunit 1 [ (human)] - National Center for ...
2025年2月9日 · The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia. The splicing factor SF3B1 confers ferroptosis resistance and promotes lung adenocarcinoma progression via upregulation of SLC7A11.
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