Sep 1, 2006 · SCG10 is a neuron-specific stathmin protein with a potent microtubule destabilizing factor and is enriched in the growth cones of the developing neurons. We investigated the functional role of SCG10 in neurite outgrowth using rat hippocampal primary cultured neurons.

Dec 26, 2012 · Here we show that superior cervical ganglion 10 (SCG10), an axonal JNK substrate, is lost rapidly from mouse dorsal root ganglion axons following axotomy. SCG10 loss precedes axon fragmentation and occurs selectively in the axon segments distal to transection that are destined to degenerate.

Jun 15, 2023 · Superior cervical ganglion-10 (SCG10, also known as stathmin-2 or STMN2) is a well-known regulator of microtubule dynamics in neurons, but its functions in the peripheral nervous system remain largely unknown.

Here, we show that axonal levels of superior cervical ganglion 10 (SCG10) is dynamically regulated after axonal injury and provides an efficient method to label regenerating axons.

Jun 26, 2023 · Superior cervical ganglion-10 (SCG10, also known as stathmin-2 or STMN2) is a well-known regulator of microtubule dynamics in neurons, but its functions in the peripheral nervous system remain largely unknown.

Dec 12, 2012 · SCG10 Undergoes Rapid JNK-Dependent Turnover in Both Injured and Healthy Axons. SCG10 is a JNK substrate, and JNK promotes axon degeneration following axotomy. Therefore, we examined whether the SCG10 loss in severed axons is mediated by JNK activity.

Feb 21, 2007 · SCG10 (superior cervical ganglia neural-specific 10 protein) is a neuron specific member of the stathmin family of microtubule regulatory proteins that like stathmin can bind to soluble tubulin and depolymerize microtubules.

Jan 1, 1997 · SCG10 is a neuron-specific protein that is membrane-associated and highly enriched in growth cones. Here we show that SCG10 binds to microtubules, inhibits their assembly, and can induce microtubule disassembly. We also show that SCG10 overexpression enhances neurite outgrowth in a stably transfected neuronal cell line.

Oct 18, 2002 · SCG10 is a neuron-specific, developmentally regulated, and nerve grwoth factor (NGF)-inducible GAP that was initially isolated as a neuronal marker of the neural crest and found to serve as a molecular marker of chromaffin cell plasticity (Stein et al., 1988).

May 29, 2015 · Superior cervical ganglion 10 (SCG10), also known as stathmin 2 (STMN2), is a neuronally expressed stathmin family protein that regulates microtubule dynamics and protein trafficking (10, 11). SCG10 is highly expressed during development and plays an important role in axonal outgrowth by modulating microtubule stability (12, 13). Interestingly ...