2024年12月25日 · SCARB1 (Scavenger Receptor Class B Member 1) is a Protein Coding gene. Diseases associated with SCARB1 include High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 and Hypoalphalipoproteinemia, Primary, 1.

2023年8月29日 · Scavenger receptor class B type I, also known as SCARB1 or CLA-1 (CD-36 and LIMPII analog 1), is a membrane protein with a molecular weight of 82 kDa that acts as the major HDL receptor and...

The SR-B1 (SCARB1) gene directs the synthesis of a membrane protein that removes cholesterol from spherical HDL. The RCT hypothesis ( Fig. 1 ), suggests SR-B1 may play an important role in the flux of cholesterol from HDL to the liver for disposal.

Mechanistically, SCARB1 inhibits ferroptosis through the regulation of cholesterol metabolism, and the upregulation of CoQ10 level is demonstrated to mediate the suppression of ferroptosis by SCARB1 after lipidomic analysis and metabolic intervention.

2016年9月20日 · Human SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL cholesterol and Lp (a). SCARB1 exonic variants often result in diminished function of translated SR-B1 via …

2008年8月1日 · Studies suggest that the SCARB1 gene may contribute to variation in plasma lipid levels at fasting; however, the results have been inconsistent, and it is unclear whether SCARB1 may also...

2025年2月8日 · SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL cholesterol and Lp(a). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a).

Using whole exome sequencing, we have identified rare, compound heterozygous variants in SCARB1 that segregate with severe, premature CAD, following patterns of Mendelian inheritance.

Scavenger receptor B type 1 (SR-B1) is a cell surface HDL receptor that mediates HDL-CE uptake. It is most abundantly expressed in liver, where it provides cholesterol for bile acid synthesis, and in steroidogenic tissues, where it delivers cholesterol needed for storage or steroidogenesis in rodents.

2025年1月18日 · SCARB1 enhances ferroptosis resistance through the upregulation of cholesterol metabolism and CoQ10. SCARB1 promotes radioresistance through the suppression of ferroptosis in tumor cells. Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation of lipid peroxides.