SAMHD1 - Wikipedia
SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in …
SAMHD1 Gene - GeneCards | SAMH1 Protein | SAMH1 Antibody
Dec 25, 2024 · SAMHD1 (SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1) is a Protein Coding gene. Diseases associated with SAMHD1 include …
SAMHD1 Functions and Human Diseases - PubMed
Mar 31, 2020 · Recent publications have identified diverse roles for SAMHD1 in double-stranded break repair, genome stability, and the replication stress response through interferon signaling. …
SAMHD1 acts at stalled replication forks to prevent interferon ...
Apr 18, 2018 · Here we show that SAMHD1 promotes degradation of nascent DNA at stalled replication forks in human cell lines by stimulating the exonuclease activity of MRE11. This …
SAMHD1 通过与 VDAC1 的相互作用维持巨噬细胞中的线粒体功能 …
SAMHD1 通过与 VDAC1 相互作用并维持线粒体功能来抑制 TLR4 诱导的急性炎症和巨噬细胞的 M1 极化，这概述了 LPS 刺激后 TLR 信号传导的新调节机制。 这些结果可以通过将全长野生型 …
SAMHD1 SAM and HD domain containing deoxynucleoside …
Jan 4, 2025 · SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA. SAMHD1 associates with inflammation and vasculitis in paediatric-onset systemic lupus …
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and ...
SAMHD1 is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is …
SAMHD1 controls innate immunity by regulating condensation of ...
Sep 22, 2022 · How vast amounts of self RNA are shielded from immune recognition to prevent autoinflammation is not fully understood. Here, we show that human SAM-domain- and HD …
SAMHD1 gene - MedlinePlus
The SAMHD1 gene provides instructions for making an enzyme that helps cut molecules called deoxynucleoside triphosphates (dNTPs). Learn about this gene and related health conditions.
研究揭示SAMHD1蛋白重要细胞学新功能_光谱网
Mar 13, 2025 · 人源SAMHD1蛋白(即包含SAM和HD结构域的I型蛋白)由我国著名免疫学家曹雪涛院士在2000年首次在人树突细胞中发现，并于2009年被认定是人体自身免疫疾病Aicardi …