SAM domain and HD domain-containing protein 1 is a protein that in humans is encoded by the SAMHD1 gene. SAMHD1 is a cellular enzyme, responsible for blocking replication of HIV in dendritic cells, [5] macrophages, [6] monocytes [7] and resting CD4 + T lymphocytes. [8]

2024年12月25日 · Complete information for SAMHD1 gene (Protein Coding), SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1, including: function, proteins, disorders, pathways, orthologs, and expression.

2018年4月18日 · Here we show that SAMHD1 promotes degradation of nascent DNA at stalled replication forks in human cell lines by stimulating the exonuclease activity of MRE11. This function activates the...

2014年2月13日 · SAMHD1 encodes the sterile α motif and histidine-aspartic domain (HD) containing protein 1, a deoxynucleoside triphosphate triphosphohydrolase that degrades the intracellular pool of deoxynucleoside triphosphates (dNTPs) into their deoxynucleosides and inorganic triphosphates (see figure). 3, 4 The final consequence of SAMHD1 activity is the dep...

SAMHD1 is a dNTPase Comprised of an N-terminal SAM Domain, a Central HD Domain, and C-Terminal Regulatory Domain.

2020年3月31日 · Recent publications have identified diverse roles for SAMHD1 in double-stranded break repair, genome stability, and the replication stress response through interferon signaling. Finally, a series of SAMHD1 mutations were also reported in various cancer cell types while why SAMHD1 is mutated in these cancer cells remains to investigated.

SAMHD1 is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause the ...

The SAMHD1 gene provides instructions for making an enzyme that helps cut molecules called deoxynucleoside triphosphates (dNTPs). Learn about this gene and related health conditions.

2025年1月4日 · SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells. SAMHD1 inhibits replication of herpes simplex virus 1 in nondividing macrophages.

2025年1月18日 · SAMHD1 is a dNTPase that impedes replication of HIV-1 in myeloid cells and resting T lymphocytes. Here we elucidate the substrate activation mechanism of SAMHD1, which involves dNTP...