2025年1月16日 · Streptomyces albus, a member of the Streptomycetaceae family, plays a significant role in natural ecosystems and industrial applications. Known for producing a wide array of secondary metabolites, this bacterium contributes to soil health and nutrient cycling.

2014年2月5日 · S. albus J1074 carries the smallest genome among the completely sequenced species of the genus Streptomyces. The detailed genome and transcriptome analysis discloses its capability to serve as a premium host for the heterologous production of natural products.

2022年7月9日 · S. epidermidis belongs to the group of coagulase-negative staphylococci (CoNS), which is different from coagulase-positive staphylococci such as S. aureus by lacking the …

S. albus J1074, by contrast, is a naturally minimized Streptomyce s strain (Baltz, 2010). A number of other Streptomyces hosts are available, which reduce production of unwanted metabolites, improve production of expressed enzymes, and/or provide a ready supply of necessary precursors (Gomez-Escribano & Bibb, 2012).

We present the complete sequence of the S. albus J1074 genome and compare it to other streptomycetes whose genomes have been sequenced. Moreover, detailed transcriptome time series of 12, 36 and 60 hours of shake-flask cultures of S. albus J1074 have been used to profile gene expression.

Streptomyces albus J1074 is a gifted heterologous host. To further improve its secondary metabolite expression capability, we rationally engineered the host by targeting genes affecting NADPH availability, precursor flux, cell growth and biosynthetic gene transcriptional activation.

The S. epidermidis agr type I is by far the most frequently isolated type from infections. The AIP of S. epidermidis agr type I inhibits all S. aureus agr types except for the rare type IV, while only S. aureus type IV inhibits S. epidermidis type I 76.

2024年7月24日 · We investigated its biosynthesis using the polyketide synthase encoded by SACE_5532 ( pks8) from Saccharopolyspora erythraea heterologously expressed in Streptomyces albus B4, a chassis chosen for its fast growth, genetic manipulability, and ample large short-chain acyl-CoA precursor supply.

Streptomyces strains are widely used hosts for heterologous expression of secondary metabolites produced by actinomycetes. These secondary metabolites are excellent starting scaffolds for the development of antibiotics, anticancer agents, immunomodulators, anthelmintic agents, and insect control agents (Baltz, 2010).

2025年3月28日 · However, James Bond star Pierce Brosnan recently commented that he has forever wished to portray the character of Dumbledore himself. Pierce Brosnan notably stars in the Guy Ritchie crime drama MobLand, which premieres on March 29. While promoting the Paramount+ show in a recent interview with the Telegraph, the veteran actor expressed his …