The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel RyR2 is an essential regulator of cardiac excitation–contraction coupling and intracellular calcium homeostasis. Mutations of the RYR2 are the cause of rare, …

2024年9月15日 · In order to determine the structural basis for the RyR2-mediated diastolic SR Ca 2+ leak observed in arrhythmic and failing hearts we solved the structures of mutant RyR2 channels that can...

Ryanodine receptor 2 (RYR2) is the pre-dominant calcium channel that releases calcium from the sarcoplasmic reticulum/endoplasmic reticulum (SR/ER) to activate cardiomyocyte contraction. Although RYR2 was previously implied as a key regulator of cardiomyocyte maturation, the mechanisms remain unclear. The aim of this study is to solve this problem.

2022年5月20日 · Cardiac ryanodine receptor (RyR2) is a large Ca 2+ release channel in the sarcoplasmic reticulum and indispensable for excitation-contraction coupling in...

2021年11月1日 · The RyR2-H29D mutation causes a diastolic SR Ca2 + leak, abnormal mechanical and electrical properties such as AP shortening and DADs and post-translational modification of the RyR2...

2022年7月20日 · Ryanodine receptor type 2 (RyR2) mutations have been linked to an inherited form of exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT results from stress-induced sarcoplasmic reticular Ca 2+ leak via the mutant RyR2 channels during diastole.

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are ...

2024年1月29日 · Concerted robust opening of cardiac ryanodine receptors’ (RyR2) Ca2+ release 1oplasmic reticulum (SR) is fundamental for normal systolic cardiac function. During diastole, infrequent spontaneous RyR2 openings mediate the SR …

2010年1月1日 · The chapter describes a kinetic model for RyR2 gating that permits prediction of the role of Ca 2+, Mg 2+, and ATP microdomains in stimulating RyR activity and SR Ca 2+ release during cardiac E–C coupling.

Ryanodine receptors (RyRs) are intracellular Ca 2+ channels that control the release of Ca 2+ from the sarco (endo)plasmic reticulum. Among the three mammalian RyR isoforms, RyR2 is primarily expressed in the heart and brain and is activated by Ca 2+ influx by a mechanism known as calcium-induced calcium release.