The RUNX2 gene provides instructions for making a protein that is involved in the development and maintenance of the teeth, bones, and cartilage. Learn about this gene and related health …

Feb 5, 2025 · Genetic ablation of POSTN + pathological fibroblasts attenuates fibrosis. Comprehensive analyses of scRNA-seq and scATAC-seq data reveal that RUNX2 is a key …

Feb 9, 2025 · Runx2 is a novel and important downstream mediator of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway that is linked to metastatic properties of breast cancer cells. Runx2 …

Dec 25, 2024 · RUNX2 (RUNX Family Transcription Factor 2) is a Protein Coding gene. Diseases associated with RUNX2 include Cleidocranial Dysplasia 1 and Metaphyseal Dysplasia With …

Runx2 is an essential transcription factor for osteoblast differentiation and chondrocyte maturation and has been considered to be required for vascular invasion into the cartilage.

Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone development. In endochondral ossification, Runx2 induces chondrocyte maturation, enhances …

Apr 10, 2023 · RUNX2 is a well-known master regulator of osteoblast and chondrocyte differentiation, but new findings have demonstrated its participation in cancer progression and …

May 8, 2020 · Nature Communications - Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway …

Sep 6, 2022 · Hojo et al. investigate the gene-regulatory landscape underlying specification of skeletal cell types in neonatal mice. Runx2, an osteoblast determinant, engages with cell-type …

Oct 23, 2014 · Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with the osteoblast phenotype. While frequently referred to, the complexity of its …