RUNX2 gene - MedlinePlus
The RUNX2 gene provides instructions for making a protein that is involved in the development and maintenance of the teeth, bones, and cartilage. Learn about this gene and related health …
RUNX2 promotes fibrosis via an alveolar-to-pathological …
2025年2月5日 · Genetic ablation of POSTN + pathological fibroblasts attenuates fibrosis. Comprehensive analyses of scRNA-seq and scATAC-seq data reveal that RUNX2 is a key …
RUNX2 Gene - GeneCards | RUNX2 Protein | RUNX2 Antibody
2024年12月25日 · RUNX2 (RUNX Family Transcription Factor 2) is a Protein Coding gene. Diseases associated with RUNX2 include Cleidocranial Dysplasia 1 and Metaphyseal …
RUNX2 RUNX family transcription factor 2 [ (human)]
2025年2月9日 · Runx2 is a novel and important downstream mediator of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway that is linked to metastatic properties of breast cancer cells. …
Whole Aspect of Runx2 Functions in Skeletal Development
Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone development. In endochondral ossification, Runx2 induces chondrocyte maturation, enhances …
Runx2: a master organizer of gene transcription in developing and ...
Runx2 is essential for osteoblast development and proper bone formation. A member of the Runt domain family of transcription factors, Runx2 binds specific DNA sequences to regulate …
A RUNX2 stabilization pathway mediates physiologic and ... - Nature
2020年5月8日 · Nature Communications - Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway …
Runx2 is required for the proliferation of osteoblast ... - Nature
2018年9月10日 · Runx2 directly regulated Fgfr2 and Fgfr3, increased the proliferation of osteoblast progenitors, and augmented the FGF2-induced proliferation. The proliferation of …
Runx2: Structure, function, and phosphorylation in osteoblast ...
Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to …
Runx2 protein may be treatment target for pulmonary fibrosis
2025年2月21日 · Runx2 “is a key driver for pulmonary fibrosis, and inactivation of [the RUNX2 gene] blocked the transition of alveolar fibroblasts to pathological fibroblasts,” the scientists …
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