2023年3月20日 · Ribonuclease inhibitor 1, also known as angiogenin inhibitor 1, encoded by RNH1, is a ubiquitously expressed leucine-rich repeat protein, which is highly conserved in mammalian species.

2024年12月25日 · RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. Diseases associated with RNH1 include Encephalitis, Acute, Infection-Induced 12 and Lung Cancer.

RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding.

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene. [5]

2021年1月28日 · RNH1, which intimately interacts with ANG to inhibit its ribonucleolytic activity, can also bind to the 40S ribosomes and control translation by yet to be known mechanisms. Here, we review recent advancement in the knowledge of …

RNH1, which intimately interacts with ANG to inhibit its ribonucleolytic activity, can also bind to the 40S ribosomes and control translation by yet to be known mechanisms. Here, we review recent advancement in the knowledge of translation regulation by the ANG-RNH1 system.

2024年5月31日 · RNH1-mediated cell type–specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type–specific global translation regulators and highlights the complex translation regulation in …

2023年3月20日 · Ribonuclease inhibitor 1, also known as angiogenin inhibitor 1, encoded by RNH1, is a ubiquitously expressed leucine-rich repeat protein, which is highly conserved in mammalian species.

2024年11月5日 · Ribonuclease Inhibitor (RNH1), conventionally known for it's role in inhibiting pancreatic ribonucleases, has emerged as a regulator of hematopoiesis, with pivotal functions in embryonic development and erythropoiesis.

2023年4月21日 · Loss-of-function mutations in the human RNH1 gene affects brain, muscles, eyes and cause infection-induced psychomotor deterioration, seizures, and macrocytic anemia. RNH1 structure is taken from...

Ribonuclease inhibitor 1, also known as angiogenin inhibitor 1, encoded by RNH1, is a ubiquitously expressed leucine-rich repeat protein, which is highly conserved in mammalian species. Inactivation of rnh1 in mice causes an embryonically lethal anemia, but the exact biological function of RNH1 in h …

Human and mouse molecular genetics have uncovered important physiological functions of Ribonuclease inhibitor 1 (RNH1). Constitutive Rnh1 knockout in mice is embryonically lethal, shows erythroid differentiation defects and anemia phenotype. Rnh1 deletion in myeloid cells increases inflammation by innate immune activators.

2016年11月11日 · Ribonuclease inhibitor (RNH1) is a cytosolic protein that binds with femtomolar affinity to human ribonuclease 1 (RNase 1) and homologous secretory ribonucleases. RNH1 contains 32 cysteine residues and has been implicated as an anti-oxidant. Here, we use CRISPR–Cas9 to knockout RNH1 in HeLa cells.

2022年11月15日 · RNH1 is known for its strong interaction with angiogenin (ANG) to inhibit its ribonucleolytic activity. Previously, we have detected RNH1 in polysome fractions and shown to regulate erythropoiesis by controlling GATA1 mRNA translation.

Our study investigates RNH1 dynamics in sepsis, its links to mortality and organ dysfunction, and the interplay with RNase 1 and RNase 5. Furthermore, we explore RNH1 as a therapeutic target in sepsis-related processes like inflammation, non …

2014年12月6日 · Ribonuclease Inhibitor (RNH1) is a ubiquitously expressed leucine-rich repeat protein. The human RNH1 gene evolved via gene duplication and is conserved among mammalian species. RNH1 binds to and inhibits pancreatic type ribonucleases.

2024年11月5日 · Ribonuclease Inhibitor (RNH1), conventionally known for it's role in inhibiting pancreatic ribonucleases, has emerged as a regulator of hematopoiesis, with pivotal functions in embryonic development and erythropoiesis.

2019年11月13日 · Recently, we have published that Ribonuclease inhibitor (RNH1) regulates erythropoiesis by controlling GATA1 mRNA translation. Here, we report that RNH1, which is present only in higher vertebrates regulates HSC cell cycle and HSC function.

2022年11月15日 · Previously, we have published that Ribonuclease inhibitor (RNH1) deletion in mice leads to defect inembryonic erythropoiesis. Here, we report that RNH1 regulates myeloid lineage choice through cyclin-dependent kinase 1 (CDK1) mediated cell cycle regulation.