2006年4月9日 · We find that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, …

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like …

黑色素瘤分化相关基因5（Melanoma differentiation-associated gene 5，简称MDA-5）也被称为IFIH1基因或Helicard基因。该基因位于染色体2q24.3上，是一个早期干扰素β反应性基因。 …

MAVS(mitochondrial antiviral signaling protein)是一种位于线粒体外膜上的信号蛋白，含有CARD结构域，在结合MDA-5/RIG-I后能招募TRAF家族蛋白，最后激活NFκB和IRF信号通路。

rig-i偏爱结合5’三磷酸基团的双链dsrna，以及较短的dsrna，而mda5则对较长的dsrna有更高的亲和力。大量的研究表明rig-i负责识别仙台病毒(sev)、水疱性口炎病毒(vsv)、新城疫病毒(ndv)和 …

MDA-5 (melanoma-differentiation-associated gene 5) and RIG-I (retinoic-acid-inducible protein 1) are cytoplasmic RNA helicases that belong to the RIG-I-like receptors (RLRs) family and are …

2008年2月1日 · This study demonstrated that RIG-I and MDA5 recognize different RNA viruses and RNA structures by generating mice deficient in RIG-I and MDA5. RIG-I −/− and MDA5 −/− …

Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and …

RIG-I and MDA5 are the principal sensors of viral dsRNA in the cytoplasm. The interferon-dependent inflammatory response triggered by RLR ligand binding is one of the first and most …

2013年9月5日 · Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5′-triphosphate (5′ …