2023年5月2日 · Trypanosoma brucei rhodesiense, found in 13 countries of eastern and southern Africa accounts for 8% of reported cases and causes an acute disease. First signs and symptoms emerge a few weeks or months after infection. The disease develops rapidly with multi-organ invasion, including the brain.

The two Trypanosoma brucei subspecies that cause African trypanosomiasis, T. b. gambiense and T. b. rhodesiense, are indistinguishable morphologically. A typical trypomastigote has a small kinetoplast located at the posterior end, a centrally located nucleus, an undulating membrane, and a flagellum running along the undulating membrane, leaving ...

Trypanosoma brucei rhodesiense causes the more virulent, East African or Rhodesian, form of African sleeping sickness and is usually transmitted by Glossina morsitans. In addition to human hosts, wild game and domestic animals in which this parasite is endemic may serve as reservoir hosts and sources of human infection.

2025年3月20日 · Because T.b. rhodesiense is maintained in animal rather than human reservoirs, rhodesiense HAT is targeted for elimination as a public health problem rather than for interruption of transmission; however, occasional human cases and localized outbreaks remain possible. This case report describes the clinical course of a traveler who developed ...

Trypanosomiasis is caused by 2 subspecies of the protozoan parasite Trypanosoma brucei (T. brucei rhodesiense and T. brucei gambiense). Trypanosomiasis is transmitted by the bite of an infected tsetse fly (Glossina spp.). Bloodborne, congenital, sexual, and transfusion or transplantation transmission are rare.

非洲锥虫病（African Trypanosomiasis）亦称睡眠病（Sleeping sickness），系由罗得西亚锥虫（Try-panosoma brucei rhodesiense）或冈比亚锥虫（Trypanosoma brucei gambiense）所致的中枢神经系统感染性疾病，借舌蝇（采采蝇）传播，流行于非洲南北纬20°之间。

2024年10月7日 · WHO has revised its rhodesiense human African trypanosomiasis treatment guidelines on the basis of an independent systematic literature review and following the GRADE methodology.

2024年6月28日 · These guidelines are providing updated evidence-based recommendations on therapeutic choices to ensure the best possible treatment for individuals infected with Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, taking into account the current therapeutic options and the different epidemiological, clinical and operational scenarios.

2024年2月24日 · Human African trypanosomiasis (HAT), or African sleeping sickness, is a potentially life-threatening infectious illness caused by the protozoans Trypanosoma brucei gambiense (T brucei gambiense) or Trypanosoma brucei rhodesiense (T brucei rhodesiense) transmitted by the tsetse fly (see Image.

rhodesiense is closely related to T. b. brucei, which only affects animals. The human infectivity of T. b. rhodesiense is conferred by a serum resistance–associated (SRA) gene product that makes the parasite resistant to lytic activity in human serum.