Dec 25, 2024 · RGS12 (Regulator Of G Protein Signaling 12) is a Protein Coding gene. Diseases associated with RGS12 include Bradyopsia and Epilepsy. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and GTPase regulator activity.

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene. [5] [6] This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor.

Sep 1, 2020 · Here, we provide evidence that regulator of G-protein signaling 12 (RGS12) is present in the mitochondria of primary chondrocytes and cartilage tissues. Deletion of RGS12 in type II...

Dec 4, 2024 · Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, …

Jun 26, 2020 · The nuclear translocation ability of NF-κB(p65) and RGS12 can both be enhanced by cyclooxygenase-2 (COX2). Furthermore, ablation of RGS12 via RNA interference significantly blocks the inflammatory process in vivo and in vitro. These results demonstrate that RGS12 plays a critical role in the pathogenesis of inflammatory arthritis.

该基因编码“G 蛋白信号调节器” (RGS) 基因家族的成员。 编码的蛋白质可以作为鸟苷三磷酸酶 (GTPase) 激活蛋白和转录抑制因子发挥作用。 这种蛋白质可能在肿瘤发生中起作用。 已经为该基因鉴定了编码不同亚型的多个转录物变体。 已经描述了其他可变剪接变体，但尚未确定它们的生物学性质。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family.

Our previous studies have revealed that regulator of G protein signaling protein 12 (Rgs12), the largest protein in the Rgs super family, is essential for osteoclastogenesis from hematopoietic cells and OC precursors. However, how Rgs12 regulates OB differentiation and function is …

RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling. RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in ...

Aug 13, 2019 · Rgs12 expression is high in mouse embryonic skeletal muscle and active satellite cells, upregulated early during muscle repair, and downregulated upon differentiation of the myoblastic C2C12 cell line.

Aug 13, 2019 · Regulators of G Protein Signaling (RGS proteins) inhibit G protein-coupled receptor (GPCR) signaling by accelerating the GTP hydrolysis rate of activated Gα subunits.