2024年12月25日 · RCOR1 (REST Corepressor 1) is a Protein Coding gene. Diseases associated with RCOR1 include Joubert Syndrome 1 and Medulloblastoma. Among its related pathways are PIP3 activates AKT signaling and Infectious disease.

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [6] RCOR1 has been shown to interact with. ^ "Human PubMed Reference:".

2022年3月23日 · RCOR1 is a known transcription repressor that recruits and positions LSD1 and HDAC1/2 on chromatin to erase histone methylation and acetylation. However, there is currently an incomplete...

The RCOR1 gene on chromosome 14 encodes a protein also called CoREST that is an essential component of a complex which represses transcription by recruiting a variety of histone modifying enzymes, methyl-DNA binding proteins, and components of …

2025年2月9日 · RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells. MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.

Based on its physical interactions with histone-modifying enzymes, the transcriptional corepressor Rcor1 has been implicated in the epigenetic regulation blood cell development. Previously, we have demonstrated that Rcor1 is essential for the maturation of …

2022年3月23日 · RCOR1 is a known transcription repressor that recruits and positions LSD1 and HDAC1/2 on chromatin to erase histone methylation and acetylation. However, there is currently an incomplete understanding of RCOR1's range of localization and function.

2014年5月15日 · The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic …

2014年5月5日 · Rcor1 represses expression of HSCs and myeloid genes during erythropoiesis, including Csf2rb, which is important in myeloid function. The corepressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation.

RCOR1 is a known transcription repressor that recruits and positions LSD1 and HDAC1/2 on chromatin to erase histone methylation and acetylation. However, there is currently an incomplete understanding of RCOR1’s range of localization and function.