2024年12月25日 · RBM14 (RNA Binding Motif Protein 14) is a Protein Coding gene. Diseases associated with RBM14 include Marginal Corneal Ulcer and Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy. Among its related pathways are Gene expression (Transcription) and RUNX2 regulates bone development.

RNA-binding protein 14 is a protein that in humans is encoded by the RBM14 gene. [5] [6]

2025年1月5日 · RBM14 connects key paraspeckle subcomplexes via interactions mediated by its prion-like domain. This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1), a nuclear protein that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs

2023年4月14日 · RNA-binding motif protein 14 (RBM14) is upregulated in a variety of tumors. However, the expression and biological role of RBM14 in lung cancer remain unclear. Chromatin immunoprecipitation and PCR were carried out to measure the levels of sedimentary YY1, EP300, H3K9ac, and H3K27ac in the RBM14 promoter.

2020年3月10日 · We propose that the cNHEJ pathway utilizes damage-induced transcription and intrinsically disordered protein RBM14 for efficient repair of DSBs. Keywords: DNA repair; RBM14; double-strand breaks. Accumulating evidence suggests participation of RNA-binding proteins with intrinsically disordered domains (IDPs) in the DNA damage response (DDR).

2024年5月28日 · By investigating the correlation between elevated O -GlcNAcylation and increased RBM14 expression in lung cancer cells, we discovered that RBM14 promotes ubiquitin-dependent proteasomal degradation of OGA, ultimately mediating cellular O …

该基因编码一种核糖核蛋白，作为一般核共激活因子和 RNA 剪接调节剂发挥作用。 该蛋白质在 N 端包含两个 RNA 识别基序 (RRM) ，在 C 端包含多个六肽重复结构域，与甲状腺激素受体结合蛋白 (TRBP) 相互作用，是转录激活所必需的。 已经针对该基因描述了编码不同同种型 (对转录具有相反作用) 的选择性剪接转录物变体。 [RefSeq 提供，2011 年 10 月] This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator.

2023年2月1日 · Our results suggest that cytoplasmic Rbm14 condensate formation regulates early embryogenesis by facilitating deadenylation, protection, and mitotic allocation of m 6 A-modified maternal mRNAs, and by releasing the poly (A)-less transcripts upon regulated disassembly to allow their re-polyadenylation and translation or clearance.

We report the discovery of functions of intrinsically disordered RNA-binding protein RBM14 in NHEJ. RBM14 and KU proteins are recruited to DSB sites and required for the generation of RNA:DNA hybrids in response to DSBs.

2022年12月9日 · 该研究揭示了Rbm14凝聚体在脊椎动物中通过协调mRNA的脱腺苷酸化、多腺苷酸化、m 6 A与m 5 C表观修饰等多个调控过程，动态又精细地调控了母源mRNA的翻译活性和稳定性。研究者推测，Rbm14凝聚体还可能通过在有丝分裂期将母源mRNA均等或差异地分配到子细胞 …