
RAS p21 protein activator 1 - Wikipedia
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities: Inactivation of Ras …
P120-Ras GTPase activating protein (RasGAP): A multi …
2009年3月1日 · p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120 …
The Ras-RasGAP complex: structural basis for GTPase activation …
1997年7月18日 · The three-dimensional structure of the complex between human H-Ras bound to guanosine diphosphate and the guanosine triphosphatase (GTPase)-activating domain of the …
Ras-Specific GTPase-Activating Proteins—Structures, …
In this review, we summarize current knowledge about RasGAP structure, mechanism, regulation, and dual-substrate specificity and discuss in some detail neurofibromin, one of the most …
RasGAPs: a crucial regulator of extracellular stimuli for …
Ras and its GTPase activating proteins (GAPs) are among the crucial regulators of extracelluar ligands. Information about these regulators has been elucidated during the course of studies in …
The Ras-RasGAP Complex: Structural Basis for GTPase ... - Science
Ras-mediated GTP hydrolysis accelerated by RasGAP is required for physiological control of a number of important signal transduction processes. Indeed, oncogenic mutants of Ras escape …
GTPase-activator protein for Ras-like GTPase - Wikipedia
The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity, referred …
Ras-Specific GTPase-Activating Proteins—Structures, Mechanisms, …
Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition state …
P120-Ras GTPase activating protein (RasGAP): A multi …
2009年3月1日 · In this review, we summarize the function of p120-RasGAP based on recent studies involved in proliferation, migration and apoptosis. We also summarize the various …
p120-Ras GTPase activating protein (RasGAP): a multi ... - PubMed
The p120-RasGAP domain participates in protein-protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the …