Dec 25, 2024 · RAD54L (RAD54 Like) is a Protein Coding gene. Diseases associated with RAD54L include Lymphoma, Non-Hodgkin, Familial and Breast Ductal Carcinoma. Among its related pathways are DNA Damage and Integrated breast cancer pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity.

RAD54L is a prominent member of the SWI2/SNF2 protein family, primarily involved in the homologous recombination repair (HRR) process, thereby playing a pivotal role in the repair of DNA double-strand breaks (DSBs). RAD54L has been …

View Therapies for RAD54L RAD54L is a predictive biomarker for use of olaparib in patients. Prostate carcinoma has the most therapies with RAD54L as a predictive biomarker.

Nov 14, 2024 · Title: Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence. Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L.

Sep 11, 2023 · RAD54L exhibits robust expression in both pan-cancer and HCC, exerting a significant influence on the proliferation and migration of HCC cells. These findings highlight its potential as a promising biomarker for pan-cancer and a prospective target for immunotherapy.

Sep 8, 2006 · HGNC Approved Gene Symbol: RAD54L. Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38) : 1:46,247,688-46,278,473 (from NCBI) Repair of double-stranded DNA breaks is essential for homologous recombination in somatic cells to protect DNA from damage by ionizing radiation and other genotoxins.

DNA repair/recombination protein 54L promotes the progression of lung adenocarcinoma by activating mTORC1 pathway. Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence.

Dec 2, 2022 · RAD54L is a DNA repair protein upregulated in several cancer types, but its role in LUAD progression remains unclear. The objective of this study was to characterise the molecular pathways that oncogenic RAD54L modulates to drive LUAD progression.

Apr 30, 2024 · Clinical resource with information about RAD54L, Familial cancer of breast, Lymphoma, non-Hodgkin, familial, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Chromosome 1: 46,713,360-46,744,145 forward strand. GRCh37:CM000663.1. This gene has 12 transcripts (splice variants), 3 paralogues and is associated with 1 phenotype. Show transcript table.