DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene. [5] The protein encoded by this gene is highly similar to Saccharomyces …

2024年12月25日 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder …

2025年3月4日 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex …

Rad50 resembles the SMC proteins involved in chromosome cohesion and chromatin condensation (Aravind et al. 1999; Strunnikov and Jessberger 1999). SMC proteins all contain …

Significance of RAD50 Mutation in Diseases Malignant Solid Tumor + RAD50 Mutation is an inclusion criterion in 26 clinical trials for malignant solid tumor, of which 21 are open and 5 are …

RAD50 is a highly conserved DNA double-strand break (DSB) repair gene. However, the associations between RAD50 germline mutations and the survival and risk of breast cancer …

2018年10月15日 · In our study, RAD50 germline mutations were determined using next-generation sequencing in 7657 consecutive unselected breast cancer patients without …

2022年5月2日 · Rad50 mediates such oligomerization, and mutations in a conserved Rad50 beta-sheet enhance or disrupt oligomerization. We demonstrate that Mre11-Rad50-Xrs2 …

2024年8月17日 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex …

Rad50 is a 150 kDa protein containing an N- and C-terminal bipartite ATPase domain, and a 900-residue insertion that forms an antiparallel coiled-coil domain.