DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene. [5] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast).

2024年12月25日 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and Hereditary Breast Ovarian Cancer Syndrome.

2025年3月4日 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends.

Rad50 resembles the SMC proteins involved in chromosome cohesion and chromatin condensation (Aravind et al. 1999; Strunnikov and Jessberger 1999). SMC proteins all contain Walker A and B nucleotide (NTP)-binding motifs at their amino- …

Significance of RAD50 Mutation in Diseases Malignant Solid Tumor + RAD50 Mutation is an inclusion criterion in 26 clinical trials for malignant solid tumor, of which 21 are open and 5 are closed.

RAD50 is a highly conserved DNA double-strand break (DSB) repair gene. However, the associations between RAD50 germline mutations and the survival and risk of breast cancer have not been fully elucidated.

2018年10月15日 · In our study, RAD50 germline mutations were determined using next-generation sequencing in 7657 consecutive unselected breast cancer patients without BRCA1/2 mutations. We also screened for RAD50 recurrent mutations (L719fs, K994fs, and H1269fs) in 5000 healthy controls using Sanger sequencing.

2022年5月2日 · Rad50 mediates such oligomerization, and mutations in a conserved Rad50 beta-sheet enhance or disrupt oligomerization. We demonstrate that Mre11-Rad50-Xrs2 oligomerization facilitates...

2024年8月17日 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends.

Rad50 is a 150 kDa protein containing an N- and C-terminal bipartite ATPase domain, and a 900-residue insertion that forms an antiparallel coiled-coil domain.