2024年12月25日 · RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include Autosomal Dominant Non-Syndromic Intellectual Disability and Charcot-Marie-Tooth Disease Type 4K. Among its related pathways are Vesicle-mediated transport and Aquaporin-mediated transport.

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene. [5][6] The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. [7]

Rab11a has a role in the trafficking of alphaVbeta3 integrin and maintenance of E-cadherin levels at the surface of endometrial epithelial cells; Reduced levels of Rab11a expression is linked to both advanced-stage carcinoma and poorer survival rates in the colorectal cancer.

2018年9月14日 · Here, we present the structure of Rab11 bound to the GEF SH3BP5, along with detailed characterization of Rab-GEF specificity. The structure of SH3BP5 shows a coiled-coil architecture that mediates...

RAB11A，成员 RAS 致癌基因家族： 该基因编码的蛋白质属于小 GTPase 超家族的 Rab 家族。 它与组成型和受调节的分泌途径相关，并可能参与蛋白质转运。 已发现该基因的两个转录本变体编码不同的亚型。

2024年6月17日 · Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy. Wang Y, et al. Genes Genomics, 2022 Nov. PMID 36125654; RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways. Gong Y, et al. Allergol Immunopathol (Madr), 2022.

<sec> 目的 探索RAB11A在鼻咽癌（NPC）中的表达情况及其对NPC细胞恶性生物学行为的影响。 </sec><sec> 方法 使用公共数据库GEO比较<italic>RAB11A</italic>在NPC组织和正常鼻咽上皮组织（NNE）中转录水平的差异，并通过western blotting以及免疫组织化学染色验证RAB11A蛋白表 …

2019年4月11日 · 惊人地 Rab11a敲除细胞显示功能性晚期内体/溶酶体以及溶酶追踪阳性细胞器的密度增加，后者主要集中在核周位置，表明内体/溶酶体途径的稳态已受到干扰。

2020年5月28日 · Our data revealed an essential role of Rab11A in promoting the cytoskeleton driven transport of dense granules and the release of their content into the vacuolar space. Rab11A also regulates transmembrane protein trafficking and localization during parasite replication, indicating a broader role of Rab11A in cargo exocytosis at the plasma membrane.

Rab11是Rab小分子GTP酶家族的成员.在细胞内膜泡再循环途径中,Rab11作为重要调节因子,介导膜泡从内体向质膜的运输.近年来随着对Rab11研究的深入,人们发现该蛋白质在多种细胞生命活动中发挥着关键作用.现对Rab11的结构,效应蛋白及功能等方面进行了综述. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不忘初心，砥砺前行。