The RTX-toxin family (subfamily of RTX-toxin superfamily) is a large family of multidomain Gram-negative bacterial pore-forming exotoxins. They are secreted from the bacteria, and after …

Resiniferatoxin (RTX) is a naturally occurring chemical found in resin spurge (Euphorbia resinifera), a cactus-like plant commonly found in Morocco, and in Euphorbia poissonii found …

The RTX toxins are virulence factors that are synthesized by a diverse group of Gram-negative pathogens . All members of the RTX toxin family share common gene organization and …

RTX toxins are large, single-chain protein toxins with molecular masses typically around 100 to 120 kDa (e.g., Escherichia coli α-hemolysin, 110 kDa).

Several RTX toxins have been shown to bind Ca 2+ in solution and to be dependent on Ca 2+ to exhibit their pore-forming and cytolytic activity. The prototype RTX toxin is the α-hemolysin …

Repeats-in-toxin (RTX) exoproteins of Gram-negative bacteria form a steadily growing family of proteins with diverse biological functions. Their common feature is the unique mode of export …

2018年1月5日 · Most RTX toxins penetrate and permeabilize host cell membranes and share several characteristic features, including (i) posttranslational modification, (ii) C-terminal …

2024年3月8日 · RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They are secreted as water-soluble proteins that are able to bind to the host …

2023年7月17日 · Both K. kingae and K. negevensis secrete a toxin called RtxA that is absent in the commensal species. Here we present a phylogenomic study of the genus Kingella, …

The various RTX toxins are syn­ thesized, modified and secreted by the products of an operon consisting of four genes in the order CABD. All RTX-toxin-encoding operons contain the linked …

Here, we focus on the biology of RTX toxins by describing salient properties of a prototype member, α-hemolysin, which is of ten encoded by strains of uropathogenic Escherichia coli. It …

1999年9月1日 · RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They fall into two categories: the hemolysins, which affect a variety of cell …

2011年6月15日 · Vibrio vulnificus is a marine bacterium causing serious septicemia and wound infection in humans. It produces an RTX toxin that can lyse a variety of cells and is important …

RTX toxins attack and kill phagocytic immune cells expressing a single integrin family, providing an obvious advantage to the pathogen. The critical question that remains, can the specificity of …

2021年5月6日 · Further, we demonstrated that Resiniferatoxin (RTX), a toxin that overactivates TRPV1 channels leading to chemical ablation of neurons, induces significant loss of sensory …

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RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They are secreted as water-soluble proteins that are able to bind to the host cell membrane …

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The repeats-in-toxins (RTX) family represents a collection of proteins from mainly Gram-negative bacterial origin [1,2,3,4]. These polypeptides vastly vary in size including molecular weights …

We identified that 60% of the strains carried a gene encoding a hitherto unrecognized member of the large repeats-in-toxins (RTX) family, which we have designated as FtxA. The clinical …