Retinal pigment epithelium and age‐related macular degeneration…
Damage to the retinal pigment epithelium (RPE) is considered to be a hallmark of AMD. There are several changes to the RPE and its surrounding microenvironment; however, some of these changes also occur over the course of normal ageing in the eye.
Functions and Diseases of the Retinal Pigment Epithelium
Here we review the function of the retinal pigment epithelium and its relevance to the pathobiology, and discuss potential strategies for the treatment of retinopathies. In doing so, we provide new viewpoints outlining new ideas for the future study and treatment of retinopathies.
Retinal Pigment Epithelium (RPE) - First Line of Defense Against …
May 26, 2016 · Research suggests that the retinal pigment epithelium (RPE) is where macular degeneration begins. This pigmented layer of cells next to the retina serves as a pass-through between the light-sensitive photoreceptors of the retina and a layer of blood vessels, called the choroid, lying below.
Retinal pigment epithelium - Wikipedia
The pigmented layer of retina or retinal pigment epithelium (RPE) is the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells.
The Retinal Pigment Epithelium in Health and Disease - PMC
Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this monolayer contrasts sharply with its importance [1].
Understanding Retinal Pigment Epithelium Changes
Jan 1, 2025 · Retinal pigment epithelium changes refer to any alterations or abnormalities in the RPE layer of the eye. These changes can include thinning, thickening, degeneration, or the presence of abnormal pigmentation.
The retinal pigment epithelium: Functions and roles in ocular …
Nov 1, 2024 · RPE dysfunction or atrophy can lead to many retinopathies, such as age-related macular degeneration and proliferative vitreoretinopathy. Here, we discuss RPE development, functions, and roles in various ocular diseases, and the mechanisms involved.
Neuroretinal and RPE changes and susceptibility to Age-Related …
These results highlight the importance of RPE-BM complex thickening in the pathophysiological sequence of AMD. Further longitudinal studies are needed, in particular to determine the value of RPE-BM thickening and PSL thinning measured using …
Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy …
Mar 22, 2019 · To describe the defining features of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA), a consensus term referring to the OCT-based anatomic changes often identified before the development of complete RPE and outer retinal atrophy (cRORA) in age-related macular degeneration (AMD).
Understanding Retinal Pigment Epithelial Changes
Jan 1, 2025 · Retinal Pigment Epithelium (RPE) is a layer of cells in the retina that plays a crucial role in supporting the function of photoreceptor cells and maintaining the health of the retina. Causes of RPE changes include aging, genetic factors, environmental factors, and certain medical conditions such as age-related macular degeneration and diabetic ...