DNA-directed RNA polymerase II subunit RPB1 – an enzyme that in humans is encoded by the POLR2A gene and in yeast is encoded by RPO21. RPB1 is the largest subunit of RNA polymerase II. It contains a carboxy terminal domain (CTD) composed of up to 52 heptapeptide repeats (YSPTSPS) that are essential for polymerase activity. [13]

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans. This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes.

2024年12月25日 · ( rpb1_human,p24928) (Microbial infection) Acts as an RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicase and transcriptase for the viral RNA circular genome.

2020年10月28日 · Stacc–seq can also detect Pol II binding using as few as 500 mESCs, using antibodies against RPB1 (the largest subunit of Pol II), regardless of the phosphorylation state of the CTD (Extended ...

RNA polymerase II largest subunit, RPB1 Stiller & Hall (1997) were the first to design primers from this molecule to resolve phylogenetic relationships. Their study focused on red algae.

RNA polymerase II (RNAP II) consists of 12 subunits and transcribes all mRNA and many noncoding RNA genes. Rpb1, the largest subunit, possesses a unique C-terminal domain (CTD) that consists of tandem heptad repeats, with a consensus sequence of Tyr-Ser-Pro-Thr-Ser-Pro-Ser (Y 1 S 2 P 3 T 4 S 5 P 6 S 7). The number of repeats, generally ...

Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity).

The C-terminal domain (CTD) of Rpb1, the largest subunit of RNA polymerase II (RNApII), coordinates recruitment of RNA- and chromatin-modifying factors to transcription complexes. It is unclear whether the CTD communicates with the catalytic core ...

RPB1 is the catalytic subunit of RNA polymerase II, which is responsible for the transcription of messenger RNAs (mRNAs) and most small nuclear RNAs and microRNAs in the nucleus (8).

2024年11月14日 · DNA-directed RNA polymerase II complex large subunit Rpb1. A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as …