Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene. [5] [6] [7] ROR1 is a member of the receptor tyrosine kinase-like …

VLS101是一款ROR1靶向ADC药物，由靶向ROR1的单克隆抗体和单甲基auristatin E (MMAE)组成，MMAE是一种通过阻断微管蛋白聚合抑制细胞分裂的药物。 VLS-101正处于临床开发，用于治疗血液系统恶性肿瘤和实体瘤患者。

1、什么是ROR1？ ROR1是受体酪氨酸激酶样孤儿受体（ROR）家族成员之一，属于I型受体酪氨酸激酶(receptor tyrosine kinase, RTK)家族。与核受体中的ROR家族不同，ROR是一类膜受体。

2024年12月25日 · ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are GPCR Pathway and ERK Signaling.

2024年11月17日 · Targeted anti-ROR1 therapy is considered a promising strategy for treating cancer because ROR1 is frequently overexpressed on the surface of cancer cells and is associated with tumorigenesis...

2017年6月15日 · Purpose: This study examines cell surface ROR1 expression in human tumors and normal tissues. ROR1 is considered a promising target for cancer therapy due to putative tumor-specific expression, and multiple groups are developing antibodies and/or chimeric antigen receptor-modified T cells to …

2025年3月4日 · 受体酪氨酸激酶样孤儿受体1（Receptor Tyrosine Kinase-Like Orphan Receptor 1, ROR1）是ROR受体家族（ROR1和ROR2）成员，属于受体酪氨酸激酶（RTK）超家族。 其结构可分为三个主要区域：

ROR1可通过介导非经典Wnt信号通路（non-canonical Wnt pathways）的信号传递，在多种生理过程中发挥重要作用，其中包括调节细胞分裂、增殖、迁移和细胞趋化。

2024年5月24日 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and serves as a biomarker and therapeutic target. It has soluble and membrane-bound subtypes, with the latter highly expressed in tum …

2024年12月14日 · ROR1是一种属于I型跨膜受体酪氨酸酸激酶蛋白，其主要通过Wnt家族蛋白结合来激活信号通路，参与细胞增殖、分化、转移和存活等生理过程。