Ribonuclease P (RNase P) is a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterised activity is the generation of mature 5'-ends of tRNAs by cleaving the 5'-leader elements of precursor-tRNAs.

The seminal discovery of ribonuclease P (RNase P) and its catalytic RNA by Sidney Altman has not only revolutionized our understanding of life, but also opened new fields for scientific exploration and investigation. This review focuses on human ...

Ribonuclease P (RNase P) is an ancient and essential endonuclease that catalyses the cleavage of the 5′ leader sequence from precursor tRNAs (pre-tRNAs). The enzyme is one of only two ribozymes which can be found in all kingdoms of life (Bacteria, ...

2006年10月1日 · Ribonuclease P (RNase P) is a ubiquitous endonuclease that catalyses the maturation of the 5′ end of transfer RNA (tRNA).

RNase P is an endo-ribonuclease required for processing precursor tRNA into mature tRNA. RNase P is a highly conserved ribonucleoprotein composed of (i) an RNA ribozyme that catalyzes RNA hydrolysis, and (ii) species-specific protein subunits.

We outline early works on human RNase P as a tRNA processing enzyme and comment on its expanding nonconventional functions in molecular networks of transcription, chromatin remodeling, homology-directed repair, and innate immunity.

RNase P is responsible for generating the mature 5′-end of tRNAs by a single endonucleolytic cleavage of their precursors. It is an essential, ubiquitous enzyme present in all cells and cellular compartments that synthesize tRNA: bacterial cells, eukaryotic nuclei, …

Ribonuclease P (RNase P) is an essential endonuclease responsible for catalyzing 5’ end maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes have been identified and studied throughout the three domains of life. ...

RNase P is an essential enzyme that catalyzes removal of the 5' leader from precursor transfer RNAs. The ribonucleoprotein (RNP) form of RNase P is present in all domains of life and comprises a single catalytic RNA (ribozyme) and a variable number of protein cofactors.

2007年5月5日 · NUCLEAR RNase P: AN ENSEMBLE OF RNA WITH HIGHLY CONSERVED PROTEINS. Ribonuclease P (RNase P) was originally described as an endoribonuclease that processes the 5′ leader sequence of precursor tRNA ( 1). In bacteria, RNase P is a small ribonucleoprotein complex ( 2), consisting of a catalytic RNA and a protein cofactor ( 3, 4).