ripk1蛋白包含三个部分：n-端激酶结构域、rip同型相互作用模块 (rhim)和c-端死亡结构域。 RIPK1具有的丝/苏氨酸激酶活性在程序性坏死、恢复体(ripoptosome)介导的半胱氨酸酶依赖的凋亡中发挥着重要作用，但是对激活NF-B通路可有可无。

2024年12月25日 · This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis.

2020年7月15日 · This article reviews RIPK1 biology and disease-associated mutations in RIPK1 signalling pathways, highlighting clinical trials of RIPK1 inhibitors and potential strategies to mitigate...

2020年8月20日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase activity, which have dem …

RIPK1 kinase has emerged as a promising therapeutic target for the treatment of a wide range of human neurodegenerative, autoimmune, and inflammatory diseases. This was supported by extensive studies which demonstrated that RIPK1 is a key mediator of apoptotic and necrotic cell death as well as inflammatory pathways.

RIPK1 is an enzyme that in humans is encoded by the RIPK1 gene, which is located on chromosome 6. [ 6 ] [ 7 ] [ 8 ] This protein belongs to the Receptor Interacting Protein (RIP) kinases family, which consists of 7 members, RIPK1 being the first member of the family.

2023年8月11日 · This review explores diseases associated with RIPK1 and its regulators, discusses RIPK1 as a therapeutic target and the development and outcome of clinical grade RIPK1 inhibitors.

2020年7月20日 · Necrostatin-1s（Nec-1s）是第一个开发的RIPK1激酶小分子抑制剂，已被广泛用于研究RIPK1在人类疾病的机理研究和动物模型中的作用。 在临床试验中，正在研究RIPK1抑制剂在多种人类疾病中的广泛治疗应用。

This review focuses on which signaling pathways use RIPK1, how activation of RIPK1 is regulated, and when activation of RIPK1 appears to be an important driver of inflammation. Receptor-interacting serine threonine kinase 1 (RIPK1) was discovered more than two decades ago because of its ability to interact with the apoptosis-inducing death ...

受体相互作用蛋白激酶1（ripk1）是由 死亡受体家族 和 模式识别受体 激活的多种信号通路的重要介体。ripk1包含一个n端激酶域，一个c端死亡域（dd）和一个包含rip同型相互作用基序（rhim）的中间域。