Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene. [5] RGS14 is a member of the regulator of G protein signalling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif.

Dec 25, 2024 · RGS14 (Regulator Of G Protein Signaling 14) is a Protein Coding gene. Diseases associated with RGS14 include Nephrolithiasis and Focal Epilepsy. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding.

In cells, RGS14 facilitates the formation of a selective Ras.GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate H-Ras-dependent neuritogenesis. This cellular function for RGS14 is similar but distinct from …

该蛋白通过其 GoLoco 结构域与特定类型的活化 GTP 结合 G α 亚基结合，从而减弱 G 蛋白的信号活性。 作为 GTP 酶激活蛋白 (GAP) ，该蛋白可提高 GTP 向 GDP 的转化率。 这种水解允许 G α 亚基结合 G β/γ 亚基异二聚体，形成无活性的 G 蛋白异三聚体，从而终止信号。 已观察到该基因的替代转录剪接变体，但尚未彻底表征。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the regulator of G-protein signaling family.

Mar 1, 2010 · RGS14 contains a GPR/GoLoco (GL) domain that forms a stable complex with inactive Giα1/3–GDP, and a tandem (R1, R2) Ras binding domain (RBD). We find that RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells. Activated H-Ras binds RGS14 at the R1 RBD to form a stable complex at cell membranes.

Feb 8, 2025 · RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.

Feb 1, 2013 · RGS14 possesses an RGS domain that binds active Gα i/o-GTP subunits to promote GTP hydrolysis and a G protein regulatory (GPR) motif that selectively binds inactive Gα i1/3-GDP subunits to form a stable heterodimer at cellular membranes. RGS14 also contains two tandem Ras/Rap binding domains (RBDs) that bind H-Ras.

Full-length and truncated forms of purified RGS14 protein were found to bind indiscriminately in vitro to both Rap- and Ras-family GTPases, consistent with prior literature reports. In stark contrast, however, we found that in a cellular context RGS14 selectively binds to activated H-Ras and not to Rap isoforms.

Regulator of G protein signaling 14 (RGS14) is a multifunctional signaling protein primarily expressed in mouse pyramidal neurons of hippocampal area CA2 where it regulates synaptic plasticity important for learning and memory. However, very little is known about RGS14 protein expression in the primate brain.

Feb 1, 2013 · Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways. RGS14 possesses an RGS domain that binds active Gα(i/o)-GTP subunits to promote GTP hydrolysis and a G protein regulatory (GPR) motif that selec …