2024年12月25日 · Complete information for RB1 gene (Protein Coding), RB Transcriptional Corepressor 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

视网膜母细胞瘤蛋白（英語： retinoblastoma protein ，常缩写为Rb、RB或RB1）又译为成视网膜细胞瘤蛋白是一种抑癌 蛋白，并在几种主要的癌症发生时失活 [6] 。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时，Rb ...

Rb是一种抑癌基因。Rb基因（Rb gene）在许多不同的癌肿里处于突变状态，但是首次报导是它在眼部恶性肿瘤（视网膜母细胞瘤retinoblastoma）发生中所起的作用。这种病具有家族性（遗传性）和散发性两种类型，家族性多见于儿童，散发性多见于成人，常为单眼受累。这种基因的蛋白质（protein）产物是 ...

2023年9月27日 · rb是这代奥德赛的底盘代号，rb1是2005年引进国内的，应该是全球同步的一款车型，07年小改也就是rb2，但是这代代号并没有普及，09年的rb3，一共这代车型进行了两次小改，所以到rb3就结束了，也就没有rb4了。

2020年4月2日 · The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and...

RB 转录辅阻遏物 1： 该基因编码的蛋白质是细胞周期的负调节因子，是第一个发现的抑癌基因。编码的蛋白质还可以稳定组成型异染色质以维持整体染色质结构。该蛋白的活性、低磷酸化形式与转录因子 E2F1 结合。该基因的缺陷是导致儿童癌症视网膜母细胞瘤 (RB) 、膀胱癌和成骨肉瘤的原因。[RefSeq ...

The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a …

The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer, the pediatric cancer retinoblastoma. The 25 years of research since its discovery has not only illuminated a general role for RB1 in …

2025年3月4日 · Title: Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance. Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.

2024年6月19日 · RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distin …