Pyrrole is a heterocyclic, aromatic, organic compound, a five-membered ring with the formula C 4 H 4 NH. [3] It is a colorless volatile liquid that darkens readily upon exposure to air. Substituted derivatives are also called pyrroles, e.g., N-methylpyrrole, C 4 H 4 NCH 3.

2000年12月4日 · Brief descriptions of the preparation and utility of some of the very large number of pyrrole derivatives are provided. These include the hydroxypyrroles, as well as aldehydes, ketones, acids, esters, and various reduced forms, such as pyrrolines and pyrrolidines.

2018年9月5日 · Pyrrole is an aromatic five membered ring with the molecular formula of C 4 H 5 N. It came in existence as a component of coal tar by F.F. Runge in 1834. Further researches showed that, it was extracted from pyrolysate of bone in 1857.

Pyrrolidine and pyrrole are widely distributed in natural products with multiple biological activities and pharmaceutically active compounds. Some pyrrole derivatives were recognized as good inhibitors against the reverse transcriptase and DNA polymerase and also exhibited a range of other bioactivities. Moreover, the pyrrolidine derivatives ...

Pyrrole derivatives show a wide range of pharmacological activity. Pyrroles could build the structure of porphyrin rings. Many of the drugs contain a pyrrole ring, for example, nootropic (Piracetam), anti-inflammatory (Indometacin), statins (Fluvastatin), neuroleptics (Molindone), drugs used to treat insomnia (Zopiclone), migraine (Sumatriptan ...

3 天之前 · An efficient synthesis of pyrrole derivatives is achieved via ordered isocyanide insertion reaction, driven by ring strain and mediated by intramolecular non-covalent bonds. This method harnesses the strategic design of precursors to control reactivity, ensuring selectivity and high yields. The strategy is noteworthy for its innovative ...

The current study describes the synthesis, physicochemical characterization and cytotoxicity evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules.

2023年6月26日 · This article highlights the applications of pyrrole derivatives in various fields, such as drug discovery, material science, and catalysis, and provides an overview of modern synthetic pathways that include metals, nanomaterials, and complex heterogeneous catalysed methods for pyrrole derivatives.

Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs.

A facile and efficient protocol enabled the synthesis of 1,2,4-substituted pyrrole derivatives from ready available starting materials. This type of reaction should have potential utility in organic synthesis.