2024年12月25日 · PYCARD (PYD And CARD Domain Containing) is a Protein Coding gene. Diseases associated with PYCARD include Muckle-Wells Syndrome and Familial Mediterranean Fever. Among its related pathways are Inflammasomes and Infectious disease.

PYCARD, known as apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), was firstly found to be related to apoptosis of human promyelocytic leukemia cancer cells treated with etoposide and all-trans retinoic acid .

2022年10月12日 · PYCARD is a protein engaged in inflammation, pyroptosis, and apoptosis. However, the function of PYCARD in human cancers remains unclear. The objective of our study was to explore PYCARD expression and prognostic value in human cancers.

2025年1月5日 · This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD).

2019年4月29日 · The NLRP3 inflammasome consists of a sensor (NLRP3), an adaptor (ASC; also known as PYCARD) and an effector (caspase 1).

2011年2月3日 · ASC, also called PYCARD /TMS1, is a bipartite protein that consists of a pyrin domain and a caspase recruitment domain (CARD) domain motif [188]. ASC is expressed in epithelial tissues and immune cells such as neutrophils and macrophages [204] .

PYCARD, also known as ASC (Apoptosis-associated speck-like protein containing a CARD), plays a crucial role in both apoptosis and inflammation. It promotes caspase-mediated apoptosis, primarily involving caspase-8, and also caspase-9 in a cell type-specific manner.

PYCARD serves as an adaptor protein with pivotal roles in assembling inflammatory responses and regulating cell apoptosis. Its functionality as an adaptor molecule is attributed to its structural domains, including the pyrin domain and the caspase activation and recruitment domain (CARD).

2024年4月24日 · PYCARD was a critical PANoptosis-related gene in all COPD patients. PYCARD was positively related to NOD-like receptor signaling pathway and promoted immune cell infiltration. Moreover, PYCARD was significantly activated in …

2025年1月5日 · This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD).