Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a 4 transmembrane domain protein which …

2024年12月25日 · This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, …

2021年11月16日 · Oligodendrocytes (OLs) produce myelin in the central nervous system (CNS), which accelerates the propagation of action potentials and supports axonal integrity. As a …

1999年6月15日 · PLP1 encodes myelin proteolipid protein 1 (PLP1), which is the predominant protein constituent of central nervous system (CNS) myelin, constituting approximately 50% of …

Proteolipid Protein 1 (PLP1) is a highly abundant myelin-associated protein in the brain that has been found to be downregulated in the prefrontal cortex of individuals with schizophrenia …

The PLP1 gene provides instructions for producing proteolipid protein 1 and a modified version (isoform) of that protein called DM20. Learn about this gene and related health conditions.

The Proteolipid Protein 1 (PLP1) gene encodes a transmembrane proteolipid protein. PLP1 is the major protein of myelin, and it plays a key role in the compaction, stabilization, and …

This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance …

2025年2月8日 · This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, …

PLP1 and DM20 are hydrophobic, post-translationally acylated, integral membrane proteins with a four-transmembrane domain structure. An intracellular loop of PLP1 resides in the major …